About: Intercellular Communication Process is a research topic. Over the lifetime, 3 publications have been published within this topic receiving 91 citations.
TL;DR: A new cell-type specific exosome reporter mouse line is generated which allows the first in vivo investigation of the localization of neuronal exosomes in the CNS, and potentially highlights the role of exosomally transferred miR-124-3p in mediating astroglial glutamate uptake function.
Abstract: Astroglia play active and diverse roles in modulating neuronal/synaptic functions in the CNS. How these astroglial functions are regulated, especially by neuronal signals, remains largely unknown. Exosomes, a major type of extracellular vesicles (EVs) that originate from endosomal intraluminal vesicles (ILVs), have emerged as a new intercellular communication process. By generating cell-type-specific ILVs/exosome reporter (CD63-GFPf/f) mice and immuno-EM/confocal image analysis, we found that neuronal CD63-GFP+ ILVs are primarily localized in soma and dendrites, but not in axonal terminals in vitro and in vivo. Secreted neuronal exosomes contain a subset of microRNAs (miRs) that is distinct from the miR profile of neurons. These miRs, especially the neuron-specific miR-124-3p, are potentially internalized into astrocytes. MiR-124-3p further up-regulates the predominant glutamate transporter GLT1 by suppressing GLT1-inhibiting miRs. Our findings suggest a previously undescribed neuronal exosomal miR-mediated genetic regulation of astrocyte functions, potentially opening a new frontier in understanding CNS intercellular communication.
TL;DR: It is claimed that the application of social and network sciences to understanding bacteria population dynamics can aid in developing better drugs to control the many pathogenic bacteria that use social interactions to cause infections.
Abstract: It is well established that bacteria engage in social behavior and form networked communities via molecular signaling. However, most studies published to date focus on the intracellular molecular networks rather than the intercellular networks formed across strains and species. Therefore, in this paper, we define for the first time a bacteria intercellular network and describe its dynamics and contribution to biofilm formation. We apply our methods to a heterogeneous bacteria population consisting of strains that are often identified from clinical isolates, namely, the wild-type (co-operator), and its signal-blind and signal-negative (cheater) mutants. We analyze the network dynamics and biofilm metrics, showing that our method can effectively reveal the underlying intercellular communication process and community organization within the biofilm. We claim that the application of social and network sciences to understanding bacteria population dynamics can aid in developing better drugs to control the many pathogenic bacteria that use social interactions to cause infections.
TL;DR: A look at how the process berween a spiritual healer and a healee works is concluded, suggesting that for the human body, non-local effects, which initially appear at the sub-atomic level, will be detectable as changes in the molecular structure of cells.
Abstract: This paper presents a hypothesis to explain the process for long distance healing. The hypothesis is based upon an integration of many areas of scientific research. We focus upon non-local inputs and their effects upon the shape of the molecules in our bodies. For hundreds of years scientists have said that if anything moved it was because something else acted on it. Nonlocality suggests that distant systems can be connected in a totally new way-a way in which distance no longer seems to matter. Recent physics experiments strongly support the existence of the phenomena. Our model suggests that for the human body, non-local effects, which initially appear at the sub-atomic level, will be detectable as changes in the molecular structure of cells. Non-local input provides guidance for maintaining the intercellular communication process essential for human gtowth and a healthy body. When noise, interference and misinformation enter into the cellular communication process the human body suffers. However, the human mind, with its ability to operate beyond the physical, permits humans to influence physical processes and hence, the healing process of a body-one's own or others. For a person to become truly connected to the non-local aspects of reality they have to "tune" their bodies to receive the intuitive non-local information. We conclude the paper with a look at how the process berween a spiritual healer and a healee works.