TL;DR: The results of the current in vitro study indicate that PF-127 gel formulations containing drug complexes with hydrophobic cyclodextrin could be useful for the preparation of a controlled delivery system of water-soluble drugs such as NTX, for a period of more than 140 hours.
Abstract: Objective:
The main objective of this study was to investigate thermosensitive Pluronic® F-127 (PF-127) hydrogel for the modified release of a potent alcohol and opioid antagonist, naltrexone (NTX) hydrochloride, in a subcutaneous injectable dosage form.
TL;DR: Capillary electrophoresis was examined as an alternative method for the determination of a recombinant cytokine in a pharmaceutical dosage form in this paper, and the results showed that capillary electrostatic analysis can separate the cytokine from its dosage form matrix adequately, rapidly and with minimum sample volume requirements.
TL;DR: An injectable or insertable dosage form comprising a biodisintegrable binder and an ablation agent in a concentration effective to cause tissue necrosis is a solid or semi-solid dosage form as mentioned in this paper.
Abstract: An injectable or insertable dosage form comprising a biodisintegrable binder and an ablation agent in a concentration effective to cause tissue necrosis. The injectable dosage form is a solid or semi-solid dosage form. Due to the solid or semi-solid nature of the dosage form, retention at the site of injection or insertion is improved, thereby improving delivery efficiency of the ablation agents within the dosage form and/or reducing the nonspecific tissue damage associated with the dosage form.
TL;DR: The results of the in vivo evaluation of the formulation in sheep indicated that a controlled release biodegradable injectable dosage form of OTC for food animals is feasible.