Increased IgG level

Abstract: The effect of dietary supplementation garlic oil on performance and blood parameters of New Zealand White rabbits has been studied. The garlic oil was added at graded levels of 0.0, 0.25, 0.5 and 0.75 g/kg for T1 (control), T2, T3 and T4, respectively. A total of thirty six male rabbits, 7 weeks of age and with an initial weigh of 950 g were used. There were four treatments, each with three replicates (n = 3) in randomly divided design. The parameters investigated were growth performance, carcass yield, glucose, plasma lipids profile, immunoglobulin’s G (IgG, IgA and IgM), antioxidant status and testosterone hormone. The results showed that feeding diet supplemented with garlic oil had insignificant effect on body weight, body weight gain, feed intake, feed conversion ratio, triglycerides, cholesterol, LDL and HDL. Rabbits fed the 0.5 g/kg garlic oil diet had significantly increased IgG level, hence improved immune responses and Testosterone hormone of rabbits. The colony forming units of coliform bacteria showed a significantly lower number compared with control. The present results indicate that supplemented of garlic oil at 0.5 g/kg of diet has a positive effect on HDL, immunoglobulin’s G, antioxidant status and testosterone hormone in addition to its antibacterial effect.

Abstract: Peritonitis is a frequent and serious complication of peritoneal dialysis (PD). Whether low immunoglobulin level is associated with PD-related peritonitis is unknown. We conducted a prospective study to assess whether immunoglobulin levels at PD onset could predict the occurrence of peritonitis. All patients starting peritoneal dialysis between 01/2005 and 12/2010 at the University hospital of Besancon, France, were included in the study. Of 240 consecutive PD patients enrolled (mean follow-up 25 ± 12 months), 76 (32 %) had at least one episode of peritonitis. Mean immunoglobulin (Ig)G level at PD start was lower in patients who subsequently experienced peritonitis (7.9 + 3.4 vs. 9.7 + 3.4 g/l, p = 0.005). An increased IgG level at PD onset was associated with a reduced risk of peritonitis [hazard ratio (HR) 0.88, 95 % confidence interval (CI) 0.80–0.97 for each increase of 1 g/l in IgG, p = 0.008]. IgG level ≤6.4 g/l (“low IgG”) was the best predictive value for the occurrence of subsequent peritonitis: 52 patients (24 %) had low IgG levels. At multivariate analysis, both low IgG level (HR 2.49, 95 % CI 1.32–4.69, p = 0.005) and diabetes (HR 2.78, 95 % CI 1.49–5.20, p = 0.001) were predictive of the occurrence of peritonitis. Low IgG levels predict the occurrence of PD-related peritonitis. Randomized studies should determine whether such patients could benefit from intravenous immunoglobulin administration.

Abstract: SIMULTANEOUS multiple primary neoplasms in a single individual are increasingly being recognized. Disordered immune surveillance might render patients to be unusually susceptible to the development of multiple tumors. 1 We report a patient with multiple myeloma who had at least three other primary neoplasms. Report of a Case An 83-year-old man had weight loss, bone pain, and anemia (hematocrit value, 22.7%). Protein electrophoresis showed a monoclonal spike in the gamma region. Immunoelectrophoresis demonstrated increased IgG levels (6.6 gm/100 ml) and decreased IgA and IgM levels. Urine immunoelectrophoresis showed an increased IgG level and lambda light chains. Bone marrow biopsy specimens showed a hypercellular marrow, with sheets of plasma cells comprising 50% of the cellular population. The serum calcium concentration was 12 mg/100 ml and serum phosphate and alkaline phosphatase levels were within normal limits. Stools were 4 + guaiac positive. The patient was treated with hydration, sodium biphosphate and a regimen

Abstract: There was investigated immunoglobulin G (IgG) to the mycoplasma (Mp) in the blood serum of women with autoimmune thyroiditis (AIT) of reproductive age and in postmenopausal periods. A control group consisted of women of similar periods without thyroid pathology. The presence of AIT was found not to be associated with increased IgG level to Mp and age factor in women. At the same time, the activity of mycoplasma infection in postmenopausal women increases both in women with AIT, and in the control group, but in women without thyroid pathology it occurs significantly more intensive (4.4-fold compared with women in reproductive period, and in AIT women — on 13.5 %). In women with AIT reliable associative links between IgG to MP and CD3, CD4, CD8, CD16 levels were not revealed. At the same time in a reproductive period there is a significant positive correlation with CD20 and negative one with CD95 (marker of Fas-mediated apoptosis), and in postmenopausal women — with a direct indicator of humoral immunity — antibodies to TG.