Topic
Immepip
About: Immepip is a research topic. Over the lifetime, 94 publications have been published within this topic receiving 4005 citations.
Papers published on a yearly basis
Papers
TL;DR: relevant information on this target protein is discussed and the development of various H3 receptor agonists and antagonists are described, and their effects in preclinical animal models are described.
Abstract: Since the cloning of the histamine H(3) receptor cDNA in 1999 by Lovenberg and co-workers, this histamine receptor has gained the interest of many pharmaceutical companies as a potential drug target for the treatment of various important disorders, including obesity, attention-deficit hyperactivity disorder, Alzheimer's disease, schizophrenia, as well as for myocardial ischaemia, migraine and inflammatory diseases. Here, we discuss relevant information on this target protein and describe the development of various H(3) receptor agonists and antagonists, and their effects in preclinical animal models.
503 citations
TL;DR: The results suggest that histamine inhibits serotonin release in the rat brain cortex via histamine H3 receptors, which may be located presynaptically.
Abstract: Rat brain cortex slices preincubated with 3H-serotonin were superfused with physiological salt solution (containing citalopram, an inhibitor of serotonin uptake) and the effect of histamine on the electrically (3 Hz) evoked 3H overflow was studied. Histamine decreased the evoked overflow in a concentration-dependent manner. The inhibitory effect of histamine was antagonized by impromidine and burimamide, but was not affected by pheniramine, ranitidine, metitepine and phentolamine. Given alone, impromidine facilitated the evoked overflow, whereas burimamide, pheniramine and ranitidine had no effect. The results suggest that histamine inhibits serotonin release in the rat brain cortex via histamine H3 receptors, which may be located presynaptically.
312 citations
TL;DR: It has been shown that S-[2-(4(5)-imidazolyl)ethylisothiourea (VUF 8325) is a potent H3-agonist measured as the electrically evoked contraction of the guinea-pig ileum.
156 citations
TL;DR: It is concluded that histamine released from histaminergic neurons facilitates short-term memory.
141 citations
TL;DR: Evidence is consistent with the proposition that activation of histamine H3 receptors leads to the selective inhibition of the component of depolarization-induced [3H]GABA release in substantia nigra pars reticulata slices which is dependent upon D1 receptor activation.
136 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2020 | 4 |
| 2019 | 3 |
| 2018 | 2 |
| 2017 | 1 |
| 2016 | 4 |
| 2015 | 4 |