TL;DR: In this paper, a single-institution, non-randomized observational study was conducted to determine whether intrauterine repair of myelomeningocele improves neurological outcomes compared with standard care.
Abstract: ContextIntrauterine closure of exposed spinal cord tissue prevents secondary
neurologic injury in animals with a surgically created spinal defect; however,
whether in utero repair of myelomeningocele improves neurologic outcome in
infants with spina bifida is not known.ObjectiveTo determine whether intrauterine repair of myelomeningocele improves
patient outcomes compared with standard care.DesignSingle-institution, nonrandomized observational study conducted between
January 1990 and February 1999.SettingTertiary care medical center.ParticipantsA sample of 29 study patients with isolated fetal myelomeningocele referred
for intrauterine repair that was performed between 24 and 30 gestational weeks
and 23 controls matched to cases for diagnosis, level of lesion, practice
parameters, and calendar time. All infants were followed up for a minimum
of 6 months after delivery.Main Outcome MeasuresRequirement for ventriculoperitoneal shunt placement, obstetrical complications,
gestational age at delivery, and birth weight for study vs control subjects.ResultsThe requirement for ventriculoperitoneal shunt placement for decompression
of hydrocephalus was significantly decreased among study infants (59% vs 91%; P = .01). The median age at shunt placement was also older
among study infants (50 vs 5 days; P = .006). This
may be explained by the reduced incidence of hindbrain herniation among study
infants (38% vs 95%; P<.001). Following hysterotomy,
study patients had an increased risk of oligohydramnios (48% vs 4%; P = .001) and admission to the hospital for preterm uterine
contractions (50% vs 9%; P = .002). The estimated
gestational age at delivery was earlier for study patients (33.2 vs 37.0 weeks; P<.001), and the birth weight of study neonates was
less (2171 vs 3075 g; P<.001).ConclusionsOur study suggests that intrauterine repair of myelomeningocele decreases
the incidence of hindbrain herniation and shunt-dependent hydrocephalus in
infants with spina bifida, but increases the incidence of premature delivery.
TL;DR: Fetuses with a left CDH who have liver herniation and a low LHR are at high risk of neonatal demise and appear to benefit from temporary tracheal occlusion when performed fetoscopically, but not when performed by open fetal surgery.
TL;DR: Over the past decade, the availability of legal abortion in the United States has permitted compilation of data necessary to evaluate the relative safety of different methods of second-trimester abortion.
Abstract: Over the past decade, the availability of legal abortion in the United States has permitted compilation of data necessary to evaluate the relative safety of different methods of second-trimester abortion. Prior to this time, clinical recommendations regarding various abortion methods were based largely on foreign data. American reports on abortion were based either on the large numbers of complications observed after illegal abortions or from small series of legally induced “therapeutic” abortions performed on high-risk patients in hospitals. This situation often resulted in clinical recommendations which were based upon uncontrolled impressions rather than on rigorous scientific observations. For example, as recently as the 1960s, a standard textbook of gynecology advised hysterotomy for all abortions at ⩾ 13 weeks’ gestation, bedrest for four to seven days after abortion by curettage, and delay “for as long as possible” before a second attempt to empty a uterus completely.1
TL;DR: It is proposed that a CSD be defined on transvaginal ultrasound or saline infusion sonohysterography as a triangular hypoechoic defect in the myometrium at the site of the previous hysterotomy.
TL;DR: An accurate approach to hemostatic procedures and uterine repair in patients with anterior placenta percreta is described to describe an accurate approach.
Abstract: Background. To describe an accurate approach, hemostatic procedures and uterine repair in patients with anterior placenta percreta. Methods. A total of 68 patients with anterior placenta percreta were included. A large retrovesical and parametrial dissection was performed in all cases. Hemostasis was achieved with selective vascular ligature or with surgical myometrial compression. The anterior wall defect was repaired using a myometrial suture, fibrin glue and polyglycolic mesh. Finally, a nonadherent cellulose layer was applied over this reconstruction. Hysteroscopy and T2 magnetic resonance imaging (MRI) were performed as a reconstruction control at 90 days after discharge. Results. Elective surgery was performed in 49 patients and emergency surgery in 19. In 59 midline incisions were performed and in nine lower transverse incisions. Forty-nine patients underwent fundal hysterotomy and 19 transplacental segmental uterine approaches. The uteri of 50 patients with anterior placenta percreta were repaired...