Topic
Hypofrontality
About: Hypofrontality is a research topic. Over the lifetime, 386 publications have been published within this topic receiving 30669 citations.
Papers published on a yearly basis
Papers
TL;DR: Functional magnetic resonance imaging was used to investigate the hypothesis that attention deficit hyperactivity disorder (ADHD) is associated with a dysfunction of prefrontal brain regions during motor response inhibition and motor timing, and hyperactive adolescents showed lower power of response.
Abstract: Objective: Functional magnetic resonance imaging (MRI) was used to investigate the hypothesis that attention deficit hyperactivity disorder (ADHD) is associated with a dysfunction of prefrontal brain regions during motor response inhibition and motor timing. Method: Generic brain activation of seven adolescent boys with ADHD was compared to that of nine comparison subjects equivalent in sex, age, and IQ while they were performing a stop task, requiring inhibition of a planned motor response, and a motor timing task, requiring timing of a motor response to a sensory cue. Results: The hyperactive adolescents showed lower power of response in the right mesial prefrontal cortex during both tasks and in the right inferior prefrontal cortex and left caudate during the stop task. Conclusions: ADHD is associated with subnormal activation of the prefrontal systems responsible for higher-order motor control. Functional MRI is a feasible technique for investigation of neural correlates of ADHD. (Am J Psychiatry 1999; 156:891‐896)
1,061 citations
TL;DR: Methodological factors addressed include the use of intersubject averaging, WM task parameters and the reliability of the measures, and factors intrinsic to schizophrenia and their relevance to the selection of experimental methods and the interpretation of group data are discussed.
733 citations
TL;DR: It is demonstrated that experimentally induced acute stress in healthy volunteers results in a reduction of WM-related DLPFC activity and reallocation of neural resources away from executive function networks, which may be explained by supraoptimal levels of catecholamines potentially in conjunction with elevated levels of cortisol.
656 citations
TL;DR: Analysis of cerebral blood flow with positron emission tomography suggests distributed dysfunctional circuits may form the neural basis of schizophrenia through cognitive impairment of the brain, which prevents it from processing input efficiently and producing output effectively, thereby leading to symptoms such as hallucinations, delusions, and loss of volition.
631 citations
TL;DR: A significant age effect was found for the prefrontal activation in both task, confirming the hypothesis of a dysmaturational pathogenesis for the hypofrontality in ADHD.
590 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 13 |
| 2020 | 8 |
| 2019 | 8 |
| 2018 | 9 |
| 2017 | 8 |
| 2016 | 14 |