Topic
Hyperprothrombinemia
About: Hyperprothrombinemia is a research topic. Over the lifetime, 18 publications have been published within this topic receiving 3403 citations. The topic is also known as: prothrombin thrombophilia & Hyperprothrombinaemia.
Papers
TL;DR: An association was found between the presence of the 20210 A allele and elevated prothrombin levels and Elevated pro thirdrombin itself also was found to be a risk factor for venous thrombosis.
3,347 citations
TL;DR: The procedure recommended is well suited for following the therapeutic effects of agents which influence the prothrombin level (or activity) such as dicumarol or vitamin K.
Abstract: SummaryThe difference between prothrombin times of whole and diluted plasma is a more reliable guide to prothrombin activity of the blood than is the prothrombin time of either alone. The difference has been found to be fairly constant in normal individuals. When prolonged, it indicates hypoprothrombinemia. When reduced, it may signify hyperprothrombinemia or an excess of anticoagulants in the blood. The procedure recommended is well suited for following the therapeutic effects of agents which influence the prothrombin level (or activity) such as dicumarol or vitamin K.
53 citations
TL;DR: Individuals with hyperprothrombinemia as a result of prothrombin gene mutations generate more thrombin and tend to be more APC‐resistant than individuals with comparable prothROMbin levels because of other causes.
50 citations
TL;DR: Data from experiments carried out in fresh liver tissue indicate that the 20210A mutation does not affect prothrombin mRNA stability but, rather, effects a change in the location of the 3'-cleavage/polyadenylation reaction.
46 citations
TL;DR: Evidence is found of an association between the paternal carriage of FV Leiden and the predisposition to recurrent pregnancy loss, thereby supporting the hypothesis that genetic contributions from both parents are essential factors in the development of this obstetric disorder.
18 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2020 | 1 |
| 2014 | 1 |
| 2013 | 2 |
| 2007 | 1 |
| 2006 | 1 |
| 2005 | 2 |