Topic
Hyperostosis
About: Hyperostosis is a research topic. Over the lifetime, 1601 publications have been published within this topic receiving 23603 citations. The topic is also known as: bone hypertrophy & hypertrophy of bone.
Papers published on a yearly basis
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Papers
TL;DR: An ankylosing disease of the spine developing in old people, with a painless onset and clinical, pathological, and radiological features distinguishing it from ankyLosing spondylitis is drawn.
Abstract: Our attention has been drawn to an ankylosing disease of the spine developing in old people, with a painless onset and clinical, pathological, and radiological features distinguishing it from ankylosing spondylitis. Some descriptions of anatomical specimens in the literature seem similar to those we have found, but no clinical or radiological studies on this subject have been published. Leri (1904) describes pathological changes in the spine of a patient suffering from a condition to which Marie and Astie (1897) gave the rather unsatisfactory name of \" heredo-traumatic kyphosis of Bechterew \", and these coincide with our observations; but in Leri's case the patient, an old man, had an angular kyphosis of the Kummel-Verneuil type consequent upon a fall. Meyer and Forster (1938) have described a similar anatomical condition under the name of \"moniliform hyperostosis \" affecting the right side of the dorsal spine. Oppenheimer (1942) noticed some ossification of vertebral ligaments in old people without involvement of the joint facets. These patients had adequate vertebral mobility and no symptoms. He considered that these features belonged to the type of ossification associated with ankylosing spondylitis. Lacapere (1949) in his study of osteophytosis of the spine in dried bones often mentions outgrowths which he calls \" melorheostosis of the spine \", a term that may lead to confusion with the disease described under this name by Leri. The anatomical description given by Lacapere coincides roughly with those of the other writers and also with that here presented. Present Investigations
705 citations
TL;DR: The extraspinal manifestations of Forestier's disease are described in 21 consecutive cases; diffuse idiopathic skeletal hyperostosis (DISH) is suggested as a more appropriate description of this ossifying diathesis.
Abstract: The extraspinal manifestations of Forestier s disease are described in 21 consecutive cases; diffuse idiopathic skeletal hyperostosis (DISH) is suggested as a more appropriate description of this ossifying diathesis. Characteristic roentgen abnormalities of the spine were present in all individuals and associated with significant axial clinical complaints. In extraspinal locations, hyperostosis at ligament attachments usually occurs in the pelvis, calcaneus, tarsal bones, ulnar olecranon and patella, and is occasionally associated with clinical signs and symptoms requiring surgery. The radiographic appearance in the peripheral skeleton is frequently distinctive and allows the radiologist to suggest the correct diagnosis, even in the absence of axial radiographs.
644 citations
Journal Article•
TL;DR: From this investigation, it appears that dermatological and osseous pictures described under various denominations, present common characteristics and transition forms justifying their common study under the acronym SAPHO (Syndrome Acne-Pustulosis-Hyperostosis-Osteitis).
Abstract: The authors report the data collected by a national investigation organized by the French Society of Rheumatology, concerning the osteo-articular manifestations of severe acne, palmo-plantar pustulosis and primary thoracic and peripheral hyperostosis. This investigation collected 85 case-reports including 13 severe acne, 44 PPP and 28 hyperostosis without the dermatitis mentioned above. From this investigation, it appears that dermatological and osseous pictures described under various denominations, present common characteristics and transition forms justifying their common study under the acronym SAPHO (Syndrome Acne-Pustulosis-Hyperostosis-Osteitis). The bony involvement, especially anterior thoracic, but also vertebral and even peripheral seems to be the common denominator between these diseases. It realizes a true rheumatoid inflammatory osteitis, osseous counterpart of synovial and cartilagenous affections in inflammatory rheumatoid diseases. This group has rather loose connections with common psoriasis and slightly more definite relationships with primary ankylosing spondylarthritis. These clinical and immunogenetic connections occur also through bony involvement.
408 citations
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TL;DR: The association of sterile inflammatory bone lesions and neutrophilic skin eruptions is the cornerstone of this new syndrome, which also has links with spondyloarthropathies and plain psoriasis.
Abstract: The occurrence of musculoskeletal manifestations (including synovitis, chest wall arthro-osteitis and multifocal aseptic osteomyelitis) in association with severe acne, palmoplantar pustulosis and perhaps with some presentations of psoriasis, have been described by many authors in the past 30 years. These different multifaceted descriptions have been designated by a variety of terms. More recently, a possible link between these conditions and spondarthritides has also been underlined by a slightly increased prevalence of HLA-B27 and occasional occurrences of sacroiliitis, chronic inflammatory bowel disease and possibly psoriasis. An acronym, the SAPHO syndrome (which stands for Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) is proposed for this group of diseases because of the similarity of musculoskeletal manifestations in patients with severe acne and pustulosis. The clinical, epidemiological, pathophysiological, immunogenetic and diagnostic aspects, as well as the management of this syndrome, are reviewed.
352 citations
TL;DR: Results indicate that hyperostosis associated with meningiomas involving the cranial base are caused by tumor invasion of the bone histologically.
Abstract: Objective Hyperostosis associated with intracranial meningiomas is a well-described entity. The cause, management, and prognosis of these bony changes have long been a point of controversy. Some authors have postulated that hyperostotic changes are secondary to the formation of the tumor and do not constitute invasion of the tumor into the bone. Determining this point has direct implications in the treatment of these patients, especially regarding surgical considerations. To more thoroughly evaluate this question, a study correlating the morphology to the radiology is necessary. Methods In this study, 51 patients underwent resection for meningiomas involving the cranial base. Preoperative radiographic evaluation using magnetic resonance imaging and/or computed tomography was performed, and areas of hyperostosis were identified. During the resection of the tumor, biopsies from these hyperostotic regions were sent for histological evaluation regarding the presence or absence of tumor invasion of the bone. Results Preoperative neuroradiological assessment identified 26 patients with radiographic evidence of hyperostosis. Histological examination of the resected bone showed tumor invasion in 35 patients, including the area of radiographically identified hyperostosis in 25 of the 26 patients. The floor of the middle fossa was a specific area of low sensitivity for preoperative assessment of associated hyperostosis. Conclusion These results indicate that hyperostosis associated with meningiomas involving the cranial base are caused by tumor invasion of the bone histologically.
298 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 40 |
| 2024 | 63 |
| 2023 | 117 |
| 2022 | 160 |
| 2021 | 49 |
| 2020 | 55 |