Topic
Hypericum canariense
About: Hypericum canariense is a research topic. Over the lifetime, 13 publications have been published within this topic receiving 393 citations.
Papers
TL;DR: Observations suggest that the methanol extract of the Hypericum species in doses of 500-1000 mg/kg p.o. possess antidepressant activity in mice, without inducing significant muscle relaxation, anticholinergic and sedative properties.
77 citations
TL;DR: The findings show that oral administration of methanol extracts, and the aqueous, butanol and chloroform fractions of both species and the infusions of Hypericum glandulosum significantly inhibit acetic acid-induced writhing in mice.
57 citations
TL;DR: Data demonstrate that the butanol and chloroform fractions from Hypericum canariense and Hypericum glandulosum possess antidepressant-like effects in mice, providing further support for the traditional use of these plants in the Canary Islands folk medicine against central nervous disorders.
36 citations
TL;DR: The observations suggest that the infusions of these Hypericum species possess antidepressant activity in mice, without inducing muscle relaxation, anticholinergic and sedative properties.
Abstract: The infusions of the aerial parts in blossom of Hypericum canariense, H. glandulosum, H. reflexum and H. grandifolium (Hypericaceae) were evaluated for their pharmacological activity on the central nervous system in mice using various behavioural models including locomotor and muscle relaxant activity, effect on normal body temperature, pentobarbital-induced sleep, oxotremorine and tetrabenazine-induced syndrome, apomorphine-induced hypothermia and 5-hydroxytryptophan-induced head twitches, as well as a forced swimming test. These infusions did not alter significantly the locomotor activity, pentobarbital induced sleeping time and body temperature, with the exception of H. canariense which produced a slight but significant hypothermia. Additionally, no muscle relaxant or anticholinergic activity were observed. These infusions antagonized the ptosis and/or motor depression induced by tetrabenazine as well as shortening the immobility time in the forced swimming test. The observations suggest that the infusions of these Hypericum species possess antidepressant activity in mice, without inducing muscle relaxation, anticholinergic and sedative properties.
23 citations
1 Apr 1991
TL;DR: To prevent the brown exudate that diffuses in the culture medium during in vitro establishment of shoots, initial explants issued from the shoot apex and axillary buds were taken from mature plants and results showed that the contamination was visible only in the explants rinsed by immersion prior to culture.
16 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2015 | 2 |
| 2010 | 1 |
| 2007 | 2 |
| 2005 | 2 |
| 2004 | 1 |
| 2002 | 4 |