Topic
Hydroxysteroid
About: Hydroxysteroid is a research topic. Over the lifetime, 391 publications have been published within this topic receiving 9639 citations. The topic is also known as: hydroxy-steroid.
Papers published on a yearly basis
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Papers
TL;DR: An increased understanding of the biochemistry and molecular biology of the STs should also provide additional information as to their functions in many normal physiologic processes.
Abstract: Conjugation of many xenobiotics, drugs, and endogenous compounds with a sulfonate moiety is an important reaction in their biotransformation. Sulfation of these compounds generally results in a decrease in biological activity and an increase in their urinary excretion. However, in certain instances, sulfation results in bioactivation to reactive electrophilic or therapeutically active forms. At least four cytosolic sulfotransferases (STs) have been identified and characterized from human tissues. These enzymes are two forms of phenol ST (PST), the phenol-sulfating and the monoamine-sulfating forms of PST (P-PST and M-PST, respectively), an estrogen sulfotransferase (EST), and a hydroxysteroid ST, dehydroepiandrosterone ST (DHEA-ST). Although four cytosolic STs have been well characterized in human tissues, evidence is accumulating for the presence of allelic forms or additional distinct forms of the STs in human tissues. The STs possess distinct but overlapping substrate specificities, and all of the STs ...
608 citations
TL;DR: It is demonstrated that individual human cy tochrome P450 enzymes can hydroxylate endogenous steroid hormones with a high degree of stereospecificity and regioselectivity, and that some, but not all of the human cytochromes exhibit metabolite profiles similar to their rodent counterparts.
331 citations
TL;DR: The source of NADPH-dependent cytosolic 3β-hydroxysteroid dehydrogenase (3β-HSD) activity is unknown to date as mentioned in this paper, but it has been shown that AKR1C catalyzes the reduction of DHT into both 3α- and 3βDiol (established by 1H NMR spectroscopy).
281 citations
TL;DR: Results indicate hydroxysteroid sulfotransferase-mediated LCA sulfation as a major pathway for protection against LCA-induced liver damage.
154 citations
TL;DR: The sequence data presented suggests that 3 alpha-HSD, prostaglandin F synthase, and aldehyde/aldose reductases are members of a common gene family.
147 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2022 | 3 |
| 2021 | 2 |
| 2020 | 2 |
| 2019 | 7 |
| 2018 | 6 |
| 2017 | 5 |