Topic
Hydroxyanthraquinone
About: Hydroxyanthraquinone is a research topic. Over the lifetime, 102 publications have been published within this topic receiving 1262 citations. The topic is also known as: monohydroxyanthraquinones & hydroxyanthraquinone.
Papers published on a yearly basis
Papers
TL;DR: The structure-radical scavenging activity relationships of the tested hydroxyanthraquinones were systematically demonstrated as follows: Hydroxy groups on one benzene ring of the anthraquinone structure were essential for hydroxyrthraquones to show activity, the ortho-dihydroxy structure in the hydroxianthra Quintone molecules could greatly enhance their radical scavenging effect, and glycosylation of the hydroxy groups reduced activity.
Abstract: The phenolic constituents in the roots of Rheum officinale and Rubia cordifolia were identified with the aid of high-performance liquid chromatography and liquid chromatography-mass spectrometry and by comparison with authentic standards. A total of 17 hydroxyanthraquinones, gallic acid, and tannins were separated, and 14 of them were identified, being the main phenolic constituents present. Their antioxidant activity (Trolox equivalent antioxidant capacity) was evaluated using the improved 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)diammonium salt method. Hydroxyanthraquinones were the predominant antioxidant phenolic constituents in the roots of R. cordifolia, and tannins and gallic acid were the predominant antioxidant phenolic constituents in the roots of R. officinale. The structure-radical scavenging activity relationships of the tested hydroxyanthraquinones were systematically demonstrated as follows: Hydroxy groups on one benzene ring of the anthraquinone structure were essential for hydroxyanthraquinones to show activity, the ortho-dihydroxy structure in the hydroxyanthraquinone molecules could greatly enhance their radical scavenging effect, and glycosylation of the hydroxyanthraquinones reduced activity.
173 citations
TL;DR: LC-diode-array detection and LC-MS provide useful complementary information for the identification of anthraquinones in plant extracts, which was proven with the identificationof munjistin and pseudopurpurin.
125 citations
TL;DR: Three new crystal structures of ATP site-directed inhibitors in complex with “casein kinase-2” (CK2), a constitutively active protein kinase implicated in a variety of cellular functions and misfunctions are presented and discussed.
78 citations
TL;DR: Five hydroxyanthraquinone compounds purified from Chinese medicinal herb rhubarb by microwave-assisted extraction and silica gel column isolation revealed an antifungal activity stronger than that of purified compounds against several plant pathogens tested.
78 citations
TL;DR: This is the first study indicating that the AE induces apoptosis specifically through the activation of caspase-6, and the AE appreciably induced cell death specific through the induction of apoptosis and by activating caspases 9/6.
Abstract: Aloe emodin (AE), a natural anthraquinone, is reported to have antiproliferative activity in various cancer cell lines. In this study, we analyzed the molecular mechanisms involved in the growth-inhibitory activity of this hydroxyanthraquinone in colon cancer cell, WiDr. In our observation AE inhibited cell proliferation by arresting the cell cycle at the G2/M phase and inhibiting cyclin B1. AE appreciably induced cell death specifically through the induction of apoptosis and by activating caspases 9/6. Apoptotic execution was found to be solely dependent on caspase-6 rather than caspase-3 or caspase-7. This is the first study indicating that the AE induces apoptosis specifically through the activation of caspase-6.
64 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 4 |
| 2020 | 2 |
| 2019 | 1 |
| 2018 | 1 |
| 2017 | 3 |
| 2016 | 2 |