Topic
Hydroxy alpha sanshool
About: Hydroxy alpha sanshool is a research topic. Over the lifetime, 2 publications have been published within this topic receiving 69 citations. The topic is also known as: hydroxy-alpha-sanshool.
Papers
TL;DR: Sanshool provides a novel pharmacological tool for discriminating functional subtypes of cutaneous mechanoreceptors and represents an essential first step in identifying the cellular and molecular mechanisms underlying tingling paresthesia that accompanies peripheral neuropathy and injury.
Abstract: Hydroxy-alpha-sanshool, the active ingredient in plants of the prickly ash plant family, induces robust tingling paresthesia by activating a subset of somatosensory neurons. However, the subtypes and physiological function of sanshool-sensitive neurons remain unknown. Here we use the ex vivo skin-nerve preparation to examine the pattern and intensity with which the sensory terminals of cutaneous neurons respond to hydroxy-alpha-sanshool. We found that sanshool excites virtually all D-hair afferents, a distinct subset of ultrasensitive light-touch receptors in the skin and targets novel populations of Abeta and C fiber nerve afferents. Thus, sanshool provides a novel pharmacological tool for discriminating functional subtypes of cutaneous mechanoreceptors. The identification of sanshool-sensitive fibers represents an essential first step in identifying the cellular and molecular mechanisms underlying tingling paresthesia that accompanies peripheral neuropathy and injury.
81 citations
TL;DR: Sanshool has been shown to reduce the magnitude of Nav17 and Nav18 currents but caused a hyperpolarizing shift in the steady-state inactivation curve as mentioned in this paper.
6 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2012 | 1 |
| 2010 | 1 |