TL;DR: A step-by-step approach is recommended for the treatment of hyperhidrosis, which affects the axillae, hands, feet, and face--areas principally involved in emotional sweating.
Abstract: Sweating is a physiological and vital process. The basic distinction is made between two types of sweating: thermoregulatory and emotional sweating. Most of the sweat glands are of the eccrine type. They produce a thin secretion that is hypotonic to plasma (e1). Eccrine sweat glands are distributed all over the body; their highest density is in the axillary region, on the palms of the hands, and on the soles of the feet (1). Their main function is thermoregulation. Apocrine sweat glands are found primarily in the axillae and the urogenital region. These scent glands become active during puberty and secrete a viscous fluid. They are responsible for a person’s "personal," occasionally unpleasant, odor (e1).
Thermoregulation is important to maintain an even body temperature and thus homeostasis (e2). Increased sweating, as in hyperhidrosis, may constitute an important problem. Those affected experience substantial impairments in terms of the social and professional environments because of increased sweat production, and the resultant subjective perception of illness at the individual level may be substantial.
This article explains the neuronal regulation of sweat secretion, aiming to deliver a better understanding of the pathophysiology of hyperhidrosis. We provide an overview of different primary and secondary hyperhidroses, their diagnosis, and therapeutic options.
TL;DR: This investigation aims to trace the course and distribution of the sympathetic sweat fibers from the superior cervical ganglion to the skin of the face and to analyze sweating responses of theFace which are apparently not transmitted by sympathetic fibers.
Abstract: The observation of sweating responses affords an excellent opportunity to study the vegetative cutaneous innervation. This is of particular physiologic and diagnostic interest in the region of the face, since other methods, such as observation of the pilomotor and vasomotor reactions, fail to give adequate information. It has been established that the sweat glands of the face, similar to those of the rest of the body, are innervated by sympathetic fibers, but there is also evidence that a parasympathetic nerve supply exists. A review of the literature reveals considerable disagreement as to the course of the sweat fibers of the face. It is therefore our endeavor in this investigation (1) to trace the course and distribution of the sympathetic sweat fibers from the superior cervical ganglion to the skin of the face and (2) to analyze sweating responses of the face which are apparently not transmitted by sympathetic fibers. Particular
TL;DR: Pressure on one side of the body does influence sweating from mental origin, and in similar conditions, pressure upon the soles or hip evokes the upper and lower sweating reflex.
Abstract: 1. In a moderately sweating condition pressure upon one side of the body evokes without exception a hemihidrosis of the opposite side.2. In similar conditions, pressure upon the soles or hip evokes the upper and lower sweating reflex.3. Pressure on one side of the body does influence sweating from mental origin.
TL;DR: The biopsy revealed an increased number of eccrine glands but no abnormality of sebaceous glands was noted; neither hypertrichosis nor comedones were seen.
Abstract: Ephidrosis, or local hyperhidrosis, in a 12-year-old girl is described. The profuse sweating was sharply limited to an area on the lateral aspect of one forearm. Hyperhidrosis was evoked by emotional stress and high environmental temperature. Sweating was normal in all other areas. The biopsy revealed an increased number of eccrine glands but no abnormality of sebaceous glands was noted; neither hypertrichosis nor comedones were seen. Systemic anticholinergics, tranquilizers, and sedatives, as well as topical anticholinergics afforded only partial or temporary relief of the very disturbing profuse sweating.
TL;DR: It has been shown that as a result of a single, prolonged episode of profuse sweating the human eccrine sweat gland undergoes characteristic cytologic changes and an orderly, progressive sequence of recovery from these changes has been observed.