TL;DR: A new method was developed for evaluating kinetically the antithrombogenicity of materials and there was good correlation between in vivo tests and in vivo observations.
Abstract: A new method was developed for evaluating kinetically the antithrombogenicity of materials. The amount of thrombus formed was measured gravimetrically at an appropriate interval of time after calcium chloride was added to ACD blood in contact with a test material. Graphic curves for thrombus formation on glass, Silastic, Hydron, and treated natural tissues were obtained and compared. There was good correlation between our in vivo tests and in vivo observations.
TL;DR: It has been verified that this layer itself improves the tolerance of the fiber by the organism, and appropriate biologically active substances, preventing either the development or spreading of an infection along the fiber, may be incorporated into the gel layer.
Abstract: Surgical suture materials were coated with a layer of hydrophilic Hydron gel. By tests carried out on tissue cultures, it has been verified that this layer itself improves the tolerance of the fiber by the organism. In addition, appropriate biologically active substances (e.g., antibiotics), preventing either the development or spreading of an infection along the fiber, may be incorporated into the gel layer. Neither the knotting ability nor other mechanical properties of the fiber are influenced by the gel coating. Preliminary clinical experiments showed good results.
TL;DR: The differences in the amount of leakage of 14 C labeled human serum albumin placed into root canals obturated with gutta-percha (lateral and vertical methods) and Hydron was determined quantitatively.
TL;DR: In this article, the rate constants for general acid catalysis of the reduction of p-benzoquinone by an NADH analog, [9- i H 2 ]- and [9 2 H 2 ], were determined in water and deuterium oxide at 25 o C.
Abstract: Rate constants for general acid catalysis of the reduction of p-benzoquinone by an NADH analog, [9- i H 2 ]- and [9- 2 H 2 ]-10-methylacridan, were determined in water and deuterium oxide at 25 o C. Catalysis by substituted acetic acids follows a BrOnsted correlation with slope α=0.85. There is a 60-fold negative deviation for hydronium ion catalysis and a 6-fold positive deviation for catalysis by cacodylic acid. For RCOOH catalysts, solvent isotope effects k L AH /k L AD range from 1.2 to 3.0 for [9-L 2 ]-10-methylacridans (L= 1 H, 2 H)
TL;DR: A discrepancy between the manufacturer's claims and findings in this study occurred regarding physical/clinical properties as well as the biocompatibility of Hydron.