TL;DR: The reconstitution of human lympho–hematopoietic cells in immunodeficient mice is demonstrated to create an in vivo model of the complete human immune system, which could permit us to generate and test novel human vaccines.
Abstract: Mouse models of human disease form a link between genetics and biology. However, mice and humans differ in many aspects of immune system biology. These differences might explain, in part, why many successful preclinical immunotherapy studies in mice turn out to be unsuccessful when used in clinical trials in humans. Pioneering studies in the late 1980s demonstrated the reconstitution of human lympho-hematopoietic cells in immunodeficient mice. Since this time, immunodeficient mice are being tested as hosts for human hematopoietic organs or cells in an effort to create an in vivo model of the complete human immune system. Such Humouse models could permit us to generate and test novel human vaccines.
TL;DR: In this article, the authors discuss the history and background of the patenting of humans and the potential negative consequences of this prohibition, and they call for the repeal and substitution of the prohibition on patenting inventions "directed to or encompassing a human organism".
Abstract: The idea of ominous technologies that put human individuals or parts of their bodies under someone else’s control has been stirring emotions and terrifying people for centuries. It was a recent offshoot of this idea — the notion of “patenting humans” — that mobilized certain members of Congress to pass legislation prohibiting the issuance of patent claims “directed to or encompassing a human organism.” The values underlying this legislation may well have been agreeable, even admirable. Yet, the actual motivation for it was misguided; its execution, deeply flawed; its potential outcomes, hazardous.This article reviews the history and background of this prohibition. It fleshes out the prohibition’s numerous flaws, including, primarily, the lack of an agreed upon definition of “human organism.” It explains why the perception that humans could be patented is part of what the article labels as the “Ownership Fallacy,” which is founded on a misunderstanding of patent laws. The article further discusses why the prohibition on the patenting of inventions “directed to or encompassing a human organism,” while unnecessary and unlikely to achieve its purpose, poses a danger to technological innovation, especially in the area of biomedical technology. The article then discusses ways of minimizing the potential negative ramifications of the prohibition by construing it narrowly. Finally, the article calls for the repeal and substitution of the prohibition on the patenting of inventions “directed to or encompassing a human organism” with a scientifically informed legislative effort aimed at expanding the boundaries of the concepts of slavery and involuntary servitude.