Topic
HTR3D
About: HTR3D is a research topic. Over the lifetime, 5 publications have been published within this topic receiving 306 citations. The topic is also known as: 5HT3D & 5-hydroxytryptamine receptor 3D.
Papers
TL;DR: The relationship between the structure and the function of the 5-HT3 receptor is reviewed, describing recent studies that have identified numerous HTR3A and H TR3B gene polymorphisms that impact upon 5- HT3 receptor function, or expression, and consider their relevance to (patho)physiology.
264 citations
TL;DR: A role of common variants of the HTR3A-E genes in OCD and OCD-related phenotypes is indicated and the use of 5-HT3 receptor antagonists as novel treatment options is supported.
25 citations
TL;DR: Information on HTR3 variants, their functional relevance, associated phenotypes, and pharmacogenetic data such as drug response and side effects are available and should help clinicians as well as scientists to evaluate their findings and to use the relevant information for subsequent genotype–phenotype correlation studies and Pharmacogenetic approaches.
Abstract: Serotonin type 3 (5-HT3) receptors are ligand-gated ion channels formed by five subunits (5-HT3A-E), which are encoded by the HTR3A, HTR3B, HTR3C, HTR3D, and HTR3E genes. Functional receptors are pentameric complexes of diverse composition. Different receptor subtypes confer a predisposition to nausea and vomiting during chemotherapy, pregnancy, and following surgery. In addition, different subtypes contribute to neurogastroenterologic disorders such irritable bowel syndrome (IBS) and eating disorders as well as comorbid psychiatric conditions. 5-HT3 receptor antagonists are established treatments for emesis and IBS and are beneficial in the treatment of psychiatric diseases. Several case–control and pharmacogenetic studies have demonstrated an association between HTR3 variants and psychiatric and neurogastroenterologic phenotypes. Recently, their potential as predictors of nausea and vomiting and treatment of psychiatric disorders became evident. This information is now available in the serotonin receptor 3 HTR3 gene allelic variant database (www.htr3.uni-hd.de), which contains five sub-databases, one for each of the five different serotonin receptor genes HTR3A-E. Information on HTR3 variants, their functional relevance, associated phenotypes, and pharmacogenetic data such as drug response and side effects are available. This central information pool should help clinicians as well as scientists to evaluate their findings and to use the relevant information for subsequent genotype–phenotype correlation studies and pharmacogenetic approaches.
18 citations
TL;DR: Insight is provided into the relationship between genetic polymorphisms in serotonin receptor family and risperidone therapeutic response in Han Chinese population and the results showed that the HTR6 rs6699866 was significantly associated with ris peridone response and predicted greater positive symptom reduction in risperodone-treated subjects.
7 citations
TL;DR: 5-HT(3) receptor antagonists are established in the therapy of CINV and irritable bowel syndrome and HTR3A and H TR3B polymorphisms may also contribute to the etiology of psychiatric disorders and serve as predictors in CINv and in the medical treatment of psychiatric patients.
Abstract: The 5-HT(3) receptor is a ligand-gated ion channel composed of five subunits. To date, five different human subunits are known, 5-HT(3AE), which are encoded by the serotonin receptor genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E, respectively. Functional receptors are pentameric complexes of diverse composition. Different receptor subtypes seem to be involved in chemotherapy-induced nausea and vomiting (CINV), irritable bowel syndrome and psychiatric disorders. 5-HT(3) receptor antagonists are established in the therapy of CINV and irritable bowel syndrome. HTR3A and HTR3B polymorphisms may also contribute to the etiology of psychiatric disorders and serve as predictors in CINV and in the medical treatment of psychiatric patients.
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2018 | 1 |
| 2017 | 1 |
| 2014 | 1 |
| 2009 | 1 |
| 2008 | 1 |