Topic
Hormesis
About: Hormesis is a research topic. Over the lifetime, 1031 publications have been published within this topic receiving 41352 citations.
Papers published on a yearly basis
Papers
TL;DR: It is argued that redox biology, rather than oxidative stress, underlies physiological and pathological conditions.
5,777 citations
TL;DR: It is indicated that glucose restriction promotes mitochondrial metabolism, causing increased ROS formation and cumulating in hormetic extension of life span, questioning current treatments of type 2 diabetes as well as the widespread use of antioxidant supplements.
1,250 citations
TL;DR: It is argued that the hormetic dose response provides the central underpinning of neuroprotective responses, providing a framework for explaining the common quantitative features of their dose-response relationships, their mechanistic foundations, and their relationship to the concept of biological plasticity.
Abstract: Despite the capacity of chaperones and other homeostatic components to restore folding equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer and in metabolic and neurodegenerative diseases. Modulation of endogenous cellular defense mechanisms represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. This article introduces the concept of hormesis and its applications to the field of neuroprotection. It is argued that the hormetic dose response provides the central underpinning of neuroprotective responses, providing a framework for explaining the common quantitative features of their dose–response relationships, their mechanistic foundations, and their relationship to the concept of biological plasticity, as well as providing a key insight for improving the accuracy of the therapeutic dose of pharmaceutical agents within the highly heterogeneous human population. This article desc...
778 citations
TL;DR: It is indicated that ROS are essential signaling molecules which are required to promote health and longevity and the concept of mitohormesis provides a common mechanistic denominator for the physiological effects of physical exercise, reduced calorie uptake, glucose restriction, and possibly beyond.
770 citations
TL;DR: Evidence from the literature shows that not only has growth hormesis been observed in a range of taxa after exposure to a variety of agents, but also that the dose-response data have a consistent form.
720 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 51 |
| 2024 | 82 |
| 2023 | 111 |
| 2022 | 204 |
| 2021 | 57 |
| 2020 | 57 |