Hold test

Abstract: Objectives This study examined the possible influence of styrene exposure on the results of vocabulary tests because verbal ability is assumed to be relatively resistant to the toxic effects of organic solvents and short vocabulary tests are used as ”hold tests” in many neurobehavioral epidemiologic studies, Methods To evaluate the chronic neurotoxic effects of styrene, a vocabulary test was administered to a group of still-exposed workers (N=27) and an earlier exposed group of workers (N=90). A self-administered questionnaire was filled out on life events, general health, educational level, and amount of education. The still-exposed group had a mean exposure duration of 4700 hours, and that for the formerly exposed group was 3610 hours. Results The vocabulary score of the still-exposed group was significantly lower [12.5 (SD 2.9, range 6-18)] than that of their former colleagues [14.3 (SD 3.4, range 8-22)], even though they originally belonged to the same group and had done the same tasks. The exposure duration explained a significant part of the vocabulary results, resulting in decreasing vocabulary scores even when the influence of years of education and age was taken into account. Even after correction for the possible influence of having been laid off or staying at work, there remained a negative influence on the vocabulary score for the duration of styrene exposure. Conclusions The use of short vocabulary tests as hold tests in cross-sectional studies of solvent-exposed workers may be limited as they seem to lack the essential toxicity-independent property.

Abstract: Background Primary intellectual abilities (PIA) are a confounder in epidemiological studies on neurotoxicity. A good measure of this confounder should be independent of age as PIA is an intrinsic ability. Furthermore, as PIA is related to health endpoints, any measure of PIA should reveal this association. This study is aimed at comparing vocabulary test, diploma and age at end of schooling properties as measures of PIA in a non-exposed population of workers. Methods The design was a cross-sectional study of 413 non-exposed workers (203 women and 210 men) selected from a health check-up center. The effect of age on the vocabulary score was assessed using an analysis of covariance adjusted for diploma. Relationships between neuropsychological performances and vocabulary score, diploma and end of schooling age were, respectively, assessed using multiple linear regressions adjusted for age and gender. Results Vocabulary score increased significantly with age, both for men and women. The increase was 0.14 word per year for women, and 0.18 word per year for men. The explained variance of the models evaluating the relationships between age at end of schooling, diploma, vocabulary test, and neuropsychological performances was quite similar for the three measures of PIA. Conclusions Vocabulary score was found to be age-related, even after adjustment for diploma. No difference was found between these three variables in terms of their relationship to neuropsychological endpoints. Moreover, the literature shows that vocabulary test performances are influenced by exposure to neurotoxic agents. These results suggest that vocabulary score could be of interest for participants of similar ages and similar diplomas. Otherwise, the other two variables would be better PIA measures in neurotoxicology studies. Am. J. Ind. Med. 2006. © 2006 Wiley-Liss, Inc.

Abstract: This study investigated the relationship between premorbid and current cognitive function with respect to the clinical features of patients with various types of neurodegeneration in the form of Alzheimer’s disease (AD), mild cognitive impairment (MCI), and subjective cognitive impairment (SCI), as compared with a healthy control group (C). Clinical features (MMSE, cognitive and depressive symptoms), genetics (apolipoprotein E; APOE) and measures of neurodegeneration (A42, t-tau, and p-tau) were examined, as well as present cognitive function. Various methods of assessing premorbid cognitive function were compared, including a Swedish NART-analogous test (Irregularly Spelled Words; ISW), a Swedish lexical decision test (SLDT), a Hold test (Information in WAIS–R), Best current performance test, and combined demographic characteristics. Results showed that cognitive decline (premorbid minus current cognitive function) based on SLDT and ISW was a significant predictor for MMSE and A42, whereas corresponding associations for present cognitive function and decline measures based on other methods were less powerful. Results also showed that specific verbal abilities (e.g., SLDT and ISW) were insensitive to AD and that these abilities indicated premorbid cognitive function in retrospect. In conclusion, cognitive decline from premorbid status reflects the disease processes.