Topic
Histamine Agents
About: Histamine Agents is a research topic. Over the lifetime, 134 publications have been published within this topic receiving 6994 citations.
Papers published on a yearly basis
Papers
TL;DR: It is shown here that histamine inhibits its own release from depolarized slices of rat cerebral cortex, an action apparently mediated by a class of receptor (H3) pharmacologically distinct from those previously characterized, that is, the H1 and H2 receptors.
Abstract: Although histaminergic neurones have not yet been histochemically visualized, there is little doubt that histamine (HA) has a neurotransmitter role in the invertebrate and mammalian central nervous system. For example, a combination of biochemical, electrophysiological and lesion studies in rats have shown that histamine is synthesized in and released from a discrete set of neurones ascending through the lateral hypothalamic area and widely projecting in the telencephalon. Histamine acts on target cells in mammalian brain via stimulation of two classes of receptor (H1 and H2) previously characterized in peripheral organs and probably uses Ca2+ and cyclic AMP, respectively, as second messengers. It is well established that several neurotransmitters affect neuronal activity in the central nervous system through stimulation not only of postsynaptic receptors, but also of receptors located presynaptically which often display distinct pharmacological specificity and by which they may control their own release. Such 'autoreceptors' have been demonstrated (or postulated) in the case of noradrenaline, dopamine, serotonin, acetylcholine and gamma-aminobutyric acid (GABA) neurones but have never been demonstrated for histamine. We show here that histamine inhibits its own release from depolarized slices of rat cerebral cortex, an action apparently mediated by a class of receptor (H3) pharmacologically distinct from those previously characterized, that is, the H1 and H2 receptors.
1,640 citations
651 citations
TL;DR: The present investigation is part of an attempt to prove an old hypothesis, namely, that this increase in permeability is mediated by histamine, and is confined to the skin of guinea-pigs.
Abstract: A substantial increase in capillary permeability is a feature of acute inflammation in bacterial infections. The present investigation is part of an attempt to prove an old hypothesis, namely, that this increase in permeability is mediated by histamine. A comparative study was made of histamine, of the histamineliberator 48/80, a condensation product ofp-methoxyphenylethylmethylamine and formaldehyde (Baltzly, Buck, de Beer & Webb, 1949), and of leukotaxine (Menkin, 1936, 1938a, b). In animals with a recently injected vital dye in their blood, the intradermal injection of substances that increase permeability of the blood vessels is followed by an accumulation of dye at the site of injection, presumably due to the passage of an excess of dye-stained plasma into the tissue spaces. When the blood flow and the vascular bed of the skin are relatively constant, differences in the size and intensity of stained areas of skin reflect differences in vascular permeability, and may be used to investigate the properties of substances that increase permeability in this way. Our work was confined to the skin of guinea-pigs, partly because much is already known about skin reactions to toxins and other inflammatory agents, and partly because it is a tissue readily studied in the intact and unanaesthetized animal-an important consideration with phenomena which, like the passage of dye through vascular endothelium, are peculiarly dependent on the state of the blood vessels in the tissue under test.
566 citations
254 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 2 |
| 2018 | 1 |
| 2017 | 1 |
| 2016 | 2 |
| 2015 | 1 |
| 2013 | 2 |