Topic
Hispolon
About: Hispolon is a research topic. Over the lifetime, 75 publications have been published within this topic receiving 1561 citations.
Papers published on a yearly basis
Papers
TL;DR: This in vivo experimental study suggests that hispolon suppresses the LPS-induced activation of inflammatory pathways, oxidative injury, ER stress, apoptosis and autophagy and has the potential to be used therapeutically in major anterior segment lung diseases.
Abstract: The anti-inflammatory effect of hispolon has identified it as one of the most important compounds from Sanghuangporus sanghuang. The research objectives were to study this compound using an animal model by lipopolysaccharide (LPS)-induced acute lung injury. Hispolon treatment reduced the production of the pro-inflammatory mediator NO, TNF-α, IL-1β, and IL-6 induced by LPS challenge in the lung tissues, as well as decreasing their histological alterations and protein content. Total cell number was also reduced in the bronchoalveolar lavage fluid (BALF). Moreover, hispolon inhibited iNOS, COX-2 and IκB-α and phosphorylated IKK and MAPK, while increasing catalase, SOD, GPx, TLR4, AKT, HO-1, Nrf-2, Keap1 and PPARγ expression, after LPS challenge. It also regulated apoptosis, ER stress and the autophagy signal transduction pathway. The results of this study show that hispolon regulates LPS-induced ER stress (increasing CHOP, PERK, IRE1, ATF6 and GRP78 protein expression), apoptosis (decreasing caspase-3 and Bax and increasing Bcl-2 expression) and autophagy (reducing LC3 I/II and Beclin-1 expression). This in vivo experimental study suggests that hispolon suppresses the LPS-induced activation of inflammatory pathways, oxidative injury, ER stress, apoptosis and autophagy and has the potential to be used therapeutically in major anterior segment lung diseases.
216 citations
TL;DR: Ethanolic extracts, hispidin and hispolon showed considerable antiviral activity against influenza viruses type A and B.
131 citations
TL;DR: The results suggest that hispolon could be useful for the treatment of gastric cancer either as a single agent or in combination with other anticancer agents.
126 citations
TL;DR: Overall the results indicate that the substitution of a hydroxyl group for a methoxy group at the meta positions of the phenyl rings in curcumin significantly enhanced the anti-inflammatory activity, and the removal of phenyl ring at the 7(th) position of the heptadiene back bone and addition of hydroxyphenyl group significantly increased theAnti-proliferative activity ofCurcumin.
113 citations
Journal Article•
TL;DR: Among all extracts, the highest amount of totalphenolicscontents were found in EtOAcfraction, and it was suggested that hispolon might contribute to itsantioxidantactivities inPM.
Abstract: This study aimed to investigate possible antioxidant activity of various extracts of Phellinus merrillii (PM). The explored items include: ABTS free radical scavenging assay, determination of total phenolics contents (TPC), ferric reducing antioxidant power assay (FRAP), rapid screening of antioxidant by dot-blot DPPH (1, 1-diphenyl-2-picrylhydrazyl) staining, DPPH radical-scavenging activities and reducing power measurement. In the ABTS free radical scavenging assay, the n-BuOH fraction displayed the highest total antioxidant activity (17.13 ± 0.04 mM). In the determination of total phenolics contents (TPC) and ferric reducing antioxidant power assay (FRAP), the EtOAc fraction had the highest phenolics contents (46.21±0.02 mM) and reducing antioxidant power (19.09±0.03 mM). In the rapid screening of antioxidant by dotblot DPPH staining, the n-BuOH fraction showed the highest strong dot-blot staining. In the reducing power measurement, the crude extract had the highest reducing power at 2 mg/ml concentration. In the DPPH radical-scavenging activities, the EtOAc fraction had the highest antioxidant activity (IC50=0.66±0.01 mg/ml). As regard the correlation coefficients among ABTS assay, FRAP assay, and total phenolics contents, it can be seen that correlation coefficients in each case were significant. Among all extracts, the highest amountof total phenolics contents were found in the EtOAc fractiont. It is suggested that the PM might ontribute its antioxidant activities on EtOAc and n-BuOH fraction. In high-performance liquid chromatography tandem mass (LC/MS/MS) analysis for hispolon, the daughter ion scanned chromatograms of PM was established. Both hispolon and PM showed similar daughter ion spectrum at the retention time of 4.7 min and had more lobes in m/z 219 and m/z 135. This indicated that PM did contain the active ingredient hispolon. Both the IC50 of DPPH radical scavenging activity for hispolon and BHT were 42.4±2.9 and 81.2 ± 3.2 μM, respectively. These findings mean that hispolon was most important in antiradical activities. It was suggested that hispolon might contribute to its antioxidant activities in PM.
111 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 6 |
| 2020 | 8 |
| 2019 | 7 |
| 2018 | 3 |
| 2017 | 7 |
| 2016 | 5 |