Topic
Hippocalcin
About: Hippocalcin is a research topic. Over the lifetime, 123 publications have been published within this topic receiving 5958 citations. The topic is also known as: BDR2 & DYT2.
Papers published on a yearly basis
Papers
TL;DR: Vertebrate retinal photoreceptors recover from photoexcitation-induced hydrolysis of guanosine 3', 5'-monophosphate (cyclic GMP) by resynthesizing cyclicGMP, which reopens cation channels that have been closed by light.
Abstract: Vertebrate retinal photoreceptors recover from photoexcitation-induced hydrolysis of guanosine 3', 5'-monophosphate (cyclic GMP) by resynthesizing cyclic GMP, which reopens cation channels that have been closed by light. Activation of guanylate cyclase by light-induced depletion of cytosolic calcium is a key event in this recovery process. This cyclase has now been shown to be regulated by a 23-kilodalton calcium binding protein. The protein is present in both rod and cone photoreceptors and was named recoverin because it promotes recovery of the dark state. The amino acid sequence of recoverin exhibits three potential calcium binding sites (EF hands). That recoverin binds calcium was confirmed with calcium-45 and by observing calcium-induced changes in its tryptophan fluorescence. Recoverin activated guanylate cyclase when free calcium was lowered from 450 to 40 nM, an effect that was blocked by an antibody to recoverin. Thus, guanylate cyclase in retinal rods is stimulated during recovery by the calcium-free form of recoverin. A comparison of recoverin with other calcium binding proteins reveals that it may represent, along with the protein visinin, a family of proteins that are regulated by submicromolar calcium concentrations.
568 citations
TL;DR: Calmodulin has been widely studied as a Ca2+ sensor that has several defined roles in neurons, but members of the neuronal calcium sensor protein family have also begun to emerge as key components in a number of regulatory pathways and have increased the diversity of neuronal Ca2+.
Abstract: In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter release and in triggering alterations in neuronal function. Calmodulin has been widely studied as a Ca(2+) sensor that has several defined roles in neuronal Ca(2+) signalling, but members of the neuronal calcium sensor protein family have also begun to emerge as key components in a number of regulatory pathways and have increased the diversity of neuronal Ca(2+) signalling pathways. The differing properties of these proteins allow them to have discrete, non-redundant functions.
559 citations
TL;DR: The specific and Ca-dependent Rv/RK interaction is necessary for the inhibitory effect of Rv on rhodopsin phosphorylation and may play an important role in photoreceptor light adaptation.
288 citations
TL;DR: These studies suggest that CSP act as functional analogues in mediating the regulation of different GRK subtypes by Ca(2+), however, this mechanism is, however, highly selective with respect to the GRk subtypes: while GRK1, but not GRK2 and GRK5, is regulated by recoverin and other NCS, GRK4, 5 and 6, are potently inhibited by CaM, which had little or no effect on members of other GR
136 citations
TL;DR: The localizations of three members of the neuronal calcium sensor (NCS) family were studied in HeLa cells and demonstrate that closely related Ca2+sensor proteins use their myristoyl groups in distinct ways in vivo in a manner that will determine the time course of Ca2- signal transduction.
135 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 2 |
| 2020 | 3 |
| 2019 | 6 |
| 2018 | 3 |
| 2017 | 3 |
| 2016 | 10 |