Topic
Hepatitis D
About: Hepatitis D is a research topic. Over the lifetime, 1090 publications have been published within this topic receiving 31664 citations. The topic is also known as: delta hepatitis & hepatitis type D.
Papers published on a yearly basis
Papers
TL;DR: A new antigen-antibody system associated with the hepatitis B virus and immunologically distinct from the HB surface, core, and e systems is reported, and delta antibody was found in the serum of chronic HBsAg carriers, with a higher prevalence in patients with liver damage.
Abstract: A new antigen-antibody system associated with the hepatitis B virus and immunologically distinct from the HB surface, core, and e systems is reported. The new antigen, termed delta, was detected by direct immunofluorescence only in the liver cell nuclei of patients with HBsAg positive chronic liver disease. At present, the intrahepatic expression of HBcAg and delta antigen appears to be mutually exclusive. No ultrastructural aspect corresponding to the delta antigen could be identified under the electron microscope. delta antibody was found in the serum of chronic HBsAg carriers, with a higher prevalence in patients with liver damage. The nuclear fluorescence patterns of HBcAg and delta antigen were similar; it is only possible to discriminate between the two antigens by using the respective specific antisera.
976 citations
TL;DR: Recent findings suggest that there is an additional form of viral hepatitis to which two recently discovered human viruses — the hepatitis .
Abstract: Chronic viral hepatitis is the principal cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma in the world and now ranks as the chief reason for liver transplantation in adults.1–3 Of the five known hepatitis viruses, three can cause persistent infection and chronic hepatitis: the hepatitis B virus (HBV),4 the hepatitis C virus (HCV),5 and the hepatitis delta (or hepatitis D) virus (HDV).6 The other two viruses, hepatitis A and hepatitis E, cause acute, self-limited disease only. Recent findings suggest that there is an additional form of viral hepatitis to which two recently discovered human viruses — the hepatitis . . .
953 citations
TL;DR: Biochemical and electron microscopic data indicate that the human hepatitis δ viral agent contains a covalently closed circular and single-stranded RNA genome that has certain similarities with viroid-like agents from plants.
Abstract: Biochemical and electron microscopic data indicate that the human hepatitis δ viral agent contains a covalently closed circular and single-stranded RNA genome that has certain similarities with viroid-like agents from plants. The sequence of the viral genome (1,678 nucleotides) has been determined and an open reading frame within the complementary strand has been shown to encode an antigen that binds specifically to antisera from patients with chronic hepatitis δ viral infections.
679 citations
TL;DR: Increased understanding of the molecular virology of HDV will identify novel therapeutic targets for this most severe form of chronic viral hepatitis, which is declining in some endemic areas but increasing in northern and central Europe because of immigration.
540 citations
TL;DR: Hepatitis B and all of the complications resulting from it, as well hepatitis D (HDV and its complications, are globally preventable by hepatitis B vaccination, and therefore elimination of HBV transmission and of new acute and chronic infections is a feasible goal.
503 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 11 |
| 2024 | 25 |
| 2023 | 49 |
| 2022 | 46 |
| 2021 | 35 |
| 2020 | 59 |