Topic
Hemolytic Process
About: Hemolytic Process is a research topic. Over the lifetime, 137 publications have been published within this topic receiving 3005 citations.
Papers published on a yearly basis
1 / 2
Papers
TL;DR: It is demonstrated that during the development of the anemia an acute aplastic condition is present in the erythropoietic tissue of the bone marrow with complete cessation of the formation of red cells, contradicting the theory that an acute increase in the hemolytic process is the reason for the crisis.
172 citations
TL;DR: The existence of anemia in a patient with chronic, stabilized hemolytic disease suggests that his bone marrow is working at or very near its capacity but despite the effort is unable to produce enough hemoglobin to maintain a normal level in the circulation.
123 citations
TL;DR: The synergistic role of hemolysis associated with severe hyperbilirubinemia in the potentiation of bilirubin-induced neurotoxicity is surveyed and methods of identifying at-risk babies with increased hemolytic activity are suggested to allow for their increased surveillance.
119 citations
TL;DR: Data obtained by means of endogenous production of carbon monoxide have shown that the mean rate of heme catabolism is approximately six times normal but varies from 3 to 14 times normal in individual patients, document the consistent presence of a severe hemolytic process in sickle cell anemia.
Abstract: The existence of hemolysis in sickle cell disease has been documented by both indirect and direct methods. The existence of bone-marrow erythroid hyperplasia, reticulocytosis, indirect hyperbilirubinemia, and elevations of plasma hemoglobin and serum lactic acid dehydrogenase values show hemolytic disease. Direct studies of erythrocyte survival, including the Ashby differential agglutination technique as well as isotopic methods have all shown a markedly decreased red blood cell survival in the range of 10 to 30 days mean cell life-span. Data obtained by means of endogenous production of carbon monoxide have shown that the mean rate of heme catabolism is approximately six times normal but varies from 3 to 14 times normal in individual patients. These data document, by a relatively new technique, the consistent presence of a severe hemolytic process in sickle cell anemia.
109 citations
TL;DR: Iradiation of erythrocytes of patients with erythropoietic protoporphyria with light of about 410 nm wavelength in the presence of oxygen, causes hemolysis, indicating that an oxidative step is involved in the process.
107 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2020 | 7 |
| 2019 | 1 |
| 2018 | 1 |
| 2017 | 2 |
| 2016 | 1 |
| 2015 | 2 |