Topic
Harmane
About: Harmane is a research topic. Over the lifetime, 223 publications have been published within this topic receiving 5323 citations. The topic is also known as: L-methylpyridobindole & 1-methyl-beta-carboline.
Papers published on a yearly basis
Papers
TL;DR: Harmaline exerted a strong antileishmanial activity toward the intracellular amastigote form of the parasite, which was shown to partly result from the capacity of the molecule to prevent parasite internalization within macrophages by inhibiting Leishmania PKC activity.
161 citations
TL;DR: It was concluded that harmane, norharmane and harmine reduce the immobility time in this test, suggesting an antidepressant-like effect, via an inverse-agonistic mechanism located in the benzodiazepine receptors.
158 citations
TL;DR: In this paper, "ready to drink" coffee brews exhibited inhibitory properties on recombinant human MAO A and B isozymes catalyzing the oxidative deamination of kynuramine, suggesting that coffee contains compounds acting as MAO inhibitors.
140 citations
TL;DR: Harmane or other related β-carbolines are putative endogenous agonists of the benzodiazepine receptor, and the observation that diazepam is equally potent in inhibiting harmane- or picrotoxin-induced convulsions is supported, indicating a convulsive mechanism within the GABA receptor-benzodiazepines receptor system.
123 citations
TL;DR: Harmane has been previously found in rat brain and human urine, so it is the most potent endogenous inhibitor of specific [3H]-flunitrazepam binding known so far, with a several hundred fold higher affinity for the benodiazepine receptor than inosine and hypoxanthine.
Abstract: The interaction of several beta-carbolines with specific [3H]-flunitrazepam binding to benzodiazepine receptors in rat brain membranes was investigated. Out of the investigated compounds, harmane and norharmane were the most potent inhibitors of specific [3H]-flunitrazepam binding, with IC50-values in the micromolar range. All other derivatives, including harmine, harmaline, and several tetrahydroderivatives were at least ten times less potent. Harmane has been previously found in rat brain and human urine, so it is the most potent endogenous inhibitor of specific [3H]-flunitrazepam binding known so far, with a several fold higher affinity for the benzodiazepine receptor than inosine and hypoxanthine. Thus, we suggest that harmane or other related beta-carbolines could be potential candidates as endogenous ligands of the benzodiazepine receptor.
118 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 2 |
| 2020 | 8 |
| 2019 | 5 |
| 2018 | 4 |
| 2017 | 6 |
| 2016 | 5 |