Topic
Haloprogin
About: Haloprogin is a research topic. Over the lifetime, 33 publications have been published within this topic receiving 313 citations. The topic is also known as: Halotex & M-1028.
Papers
TL;DR: In this paper, the formation of three polymorphs of haloprogin and of three co-crystals that this active pharmaceutical ingredient forms with both neutral and ionic cocrystal formers is described.
Abstract: Haloprogin is a topical antifungal agent. Its structure does not contain any of the functional groups typically exploited in hydrogen bond based co-crystal design. On the other hand, its 1-iodoalkyne moiety is nicely tailored to a crystal engineering strategy based on halogen bonding. Here we describe the formation of three polymorphs of haloprogin and of three co-crystals that this active pharmaceutical ingredient forms with both neutral and ionic co-crystal formers. The halogen bond plays a major role in all of the six structures and the interaction is thus confirmed to be a valuable tool which may complement the hydrogen bond when polymorphs and co-crystals of active pharmaceutical ingredients are pursued.
49 citations
TL;DR: Based on its broad spectrum of antimicrobial activity, haloprogin may prove to be a superior topical agent in the treatment of dermatophytic and monilial infections in man.
Abstract: Haloprogin was shown to be a highly effective agent for the treatment of experimentally induced topical mycotic infections in guinea pigs. Its in vitro spectrum of activity also includes yeasts, yeastlike fungi (Candida species), and certain gram-positive bacteria. The in vitro and in vivo antifungal activity of haloprogin against dermatophytes was equal to that observed with tolnaftate. The striking differences between the two agents were the marked antimonilial and selective antibacterial activities shown by haloprogin, contrasted with the negligible activities found with tolnaftate. Addition of serum decreased the in vitro antifungal activity of haloprogin to a greater extent than that of tolnaftate; however, diminished antifungal activity was not observed when haloprogin was applied topically to experimental dermatophytic infections. Based on its broad spectrum of antimicrobial activity, haloprogin may prove to be a superior topical agent in the treatment of dermatophytic and monilial infections in man.
30 citations
TL;DR: A double-blind study revealed that haloprogin is an effective preparation compared to placebo and tolnaftate are equally effective in the treatment of dermatophytosis.
Abstract: Haloprogin is a new topical antifungal medication. A double-blind study revealed that haloprogin is an effective preparation compared to placebo. Haloprogin and tolnaftate are equally effective in the treatment of dermatophytosis.
21 citations
TL;DR: All the drugs were totally effective against experimental infection if the inoculation was immediate, however, after 48 h the effects of haloprogin and tolnaftate were greatly reduced, but the others were still very effective.
Abstract: SUMMARY
Topical antifungal agents, 1% haloprogin solution (Halotex®), 1% tolnaftate solution (Tinactin®), 1% sodium omadine cream and 5% thiabendazole in dimethylacetamide have been investigated. They were tested for prophylactic effect against experimental human Trichophyton mentagrophytes infections. All the drugs were totally effective against experimental infection if the inoculation was immediate. However, after 48 h the effects of haloprogin and tolnaftate were greatly reduced, but the others were still very effective.
Statum corneum may be stripped onto a tape, sterilized and then inoculated with T.mentagrophytes spores. Under controlled conditions the spores germinate in vitro in the stratum corneum. This method has been quantitated and adapted to the investigation of topical antifungal agents. Results show that tolnaftate has very title antifungal activity even at zero time, thiabendazole and sodium omadine retain excellent activity in the stratum corneum for 48 h and are readily detectable even 72 h after one application.
21 citations
TL;DR: Two studies indicate haloprogin cream to be significantly more efficacious in experimentally induced and naturally occurring human infections than previously thought.
Abstract: One percent haloprogin cream, a topical agent for the treatment of dermatophytoses, has proved efficacious in experimentally induced and naturally occurring human infections. These studies indicate haloprogin cream to be significantly (P
19 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2014 | 1 |
| 2009 | 5 |
| 1989 | 1 |
| 1986 | 1 |
| 1982 | 1 |
| 1980 | 2 |