TL;DR: A mixture of flavonoids extracted from the plant Grangea maderaspatana possessed oestrogenicity and antiimplantational activities in the mouse and proved to be mildly oestrogensic.
Abstract: A mixture of flavonoids extracted from the plant Grangea maderaspatana possessed oestrogenicity and antiimplantational activities in the mouse. In the 3 day uterotrophic bioassay, administration of the drug at a dose of 20 mg/kg body weight per day, intramuscularly to ovariectomized females, resulted in a highly significant (p < 0.001) increase in the wet uterine and vaginal weights. However, in comparison with conjugated oestrogen, the extract proved to be mildly oestrogenic. Flavonoids, if administered orally at the same dose level effectively interfere with all stages of pregnancy. Maximum interceptory efficacy was recorded when the drug was administered from days 4-6 post coitum. However, there was a reduction in antinidational activity only if the drug was administered from days 1-3 and 7-9 post coitum
TL;DR: Six species belonging to the genera Ceruana,conyza, Conyzanthus and Grangea, tribe Astereae (Compositae), were investigated for their flavonoids and Glycosides identified were found to belong to the aglycones kaempferol, quercetin, luteolin, scutellarein and hispidulin.
TL;DR: Beentje et al. as discussed by the authors reevaluate the distinction between the genera Grangea Adans and Akeassia and describe a new Gabonese species of Asteraceae from Gabon.
Abstract: Beentje, H. & O. Lachenaud (2020). The inclusion of Akeassia in Grangea (Asteraceae) and description of a new species from Gabon: Grangea ogoouensis. Candollea 75: 311 – 319. In English, English and French abstracts.The discovery of a new Gabonese species of Asteraceae leads us to reevaluate the distinction between the genera Grangea Adans. and Akeassia J.-P. Lebrun & Stork. The differences between the two genera proving unreliable, Akeassia is included in Grangea, resulting in the new combination Grangea grangeoides (J.-P. Lebrun & Stork) Beentje & O. Lachenaud. A key to the ten species of Grangea is presented, as well as complete morphological descriptions for the three species occurring in Gabon: Grangea grangeoides, Grangea maderaspatana (L.) Desf., and and the new species Grangea ogoouensis O. Lachenaud & Beentje. The new species differs from Grangea grangeoides by its pinnatifid lower leaves and more numerous pappus-bristles, and from Grangea maderaspatana by its free pappus bristles and smaller phyllaries. It appears to be endemic to Gabon, and its conservation status is assessed as “Vulnerable”.