Topic
Gonane
About: Gonane is a research topic. Over the lifetime, 28 publications have been published within this topic receiving 455 citations.
Papers
TL;DR: It has been amply proven that - even when administered in doses that do not constantly inhibit ovulation - a progestin can still remain effective as a contraceptive by acting at the level of the cervical mucus and, at least in part, of the endometrium.
Abstract: The term progestogen has been widely utilized to indicate the general class of agents that includes both progesterone and its synthetic analogs, whereas the term progestin refers only to synthetic progestational steroids. The development of progestins has been influenced in a major way by the search for orally active hormonal contraceptives, since it is likely that hormonal contraceptives will continue to utilize a progestin, the only possible alternative being represented by the utilization of antiprogestins. Synthetic progestogens in clinical use today belong to three main chemical families: progesterone derivatives (progesterone, retro-progesterone, 19-norprogesterone and 17α-hydroxyprogesterone); gonane and 19-nortestosterone derivatives (norethisterone, levonorgestrel, desogestrel, gestodene, norgestimate); a spironolactone derivative. Biological potency of progestogens varies depending on the end-point measured, usually ovulation inhibition and endometrial transformation; with both these tests, the ...
67 citations
TL;DR: The current, informal method for classifying oral contraceptives as old, first generation, or second generation on the basis of their date of introduction obscures the fact that each of the gonane progestins has unique biologic properties.
43 citations
TL;DR: Biological study of 7alpha- and 7beta- alkyl derivatives of steroidal 4,6-dien-3-ones of the androstane, estrane and gonane series revealed that the contragestative effects were associated with the latter anti-hormonal properties, and not with the androgenicity of these compounds.
35 citations
TL;DR: A review of more than 50 clinical studies suggests that desogestrel differs from progestins currently used in oral contraception in that it does not interfere with the estrogen effects on lipoprotein metabolism.
25 citations
TL;DR: This review summarizes the influence of different contraceptive steroid combinations on glucose metabolism and points to the possible mechanisms behind a disturbance of the euglycemic homeostasis with a concomitant change in lipid metabolism.
22 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2015 | 1 |
| 2011 | 1 |
| 2009 | 1 |
| 2004 | 1 |
| 1999 | 1 |
| 1998 | 2 |