Topic
GNMT
About: GNMT is a research topic. Over the lifetime, 210 publications have been published within this topic receiving 6702 citations. The topic is also known as: HEL-S-182mP & glycine N-methyltransferase.
Papers published on a yearly basis
Papers
TL;DR: It is established that the abundance of the mRNA of the main genes involved in methionine metabolism is markedly reduced in human cirrhosis and HCC, and Interestingly, MAT1A promoter was hypermethylated in the cirrhotic liver.
343 citations
TL;DR: In this article, S-adenosylmethionine (SAMe) was shown to be a key metabolite that regulates hepatocyte growth, death, and differentiation.
309 citations
TL;DR: It is demonstrated that loss of GNMT induces aberrant methylation of DNA and histones, resulting in epigenetic modulation of critical carcinogenic pathways in mice.
296 citations
TL;DR: It is postulated that the glycine methyltransferase serves a role in regulating the relative levels of S-adenosylmethionine and S- adenosylhomocysteine, thus exerting some control over those methyltransferases whose activity is more sensitive to the action of S -adenosyhomocy steine.
286 citations
TL;DR: Evidence is presented that 5-methyltetrahydropteroylpentaglutamate (5-CH3-H4PteGlu5) is bound with high specificity, and is a powerful inhibitor of the enzyme Glycine N-methyltransferase.
180 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2022 | 1 |
| 2021 | 10 |
| 2020 | 9 |
| 2019 | 9 |
| 2018 | 10 |
| 2017 | 5 |