Topic
Glutarates
About: Glutarates is a research topic. Over the lifetime, 116 publications have been published within this topic receiving 1762 citations.
Papers published on a yearly basis
Papers
TL;DR: In this article, the particle size and structure of zinc glutarates were determined by wide-angle X-ray diffraction, transmission electron microscopy, and the laser particle size analyzer technique.
Abstract: Zinc glutarates were synthesized from zinc oxides with varying purities via different stirring routes. The particle size and structure of these zinc glutarates were determined by wide-angle X-ray diffraction, transmission electron microscopy, and the laser particle size analyzer technique. The results demonstrated that the crystallinity and crystalline perfectness of zinc glutarate are the crucial factors that affect the catalytic activity for the copolymerization of carbon dioxide (CO2) and propylene oxide (PO). Additionally, the catalyst with a small particle size dramatically increased the yield of the copolymerization between CO2 and PO. High-molecular-weight and regular molecular structure poly(propylene carbonate)s (PPC)s were obtained from CO2 and PO with the synthesized zinc glutarates. Very high catalytic activity of 160.4 g polymer/g catalyst was afforded. The NMR technique revealed that the PPC copolymer exhibits an exact alternating copolymer structure. The relationships between the crystallinity and the particle size of catalyst with the catalytic activity are correlated and discussed. © 2002 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 40: 3579–3591, 2002
141 citations
TL;DR: Speculation that cerebral metabolism normally functions at close to its maximal capacity and cannot, therefore, be increased has been refuted by the findings of stimulation of cerebral oxygen consumption in vivo by epinephrine and related drugs.
Abstract: NUMEROUS studies have demonstrated that the mature brain, unlike most other tissues,' does not participate in the overall increase in total body metabolic rate in hyperthyroidism (GORDON and HEMING, 1944; SCHEINBERG, 1950; SOKOLOFF, WECHSLER, MANGOLD, BALLS and KETY, 1953 ; SENSENBACH, MADISON, EISENBERG and OCHS, 1954). Attempts to explain the lack of thyroxine effect on cerebral oxygen consumption have proved to be inadequate. Speculation that cerebral metabolism normally functions at close to its maximal capacity and cannot, therefore, be increased (SCHEINBERG, 1950; FAZEKAS, GRAVES and ALMAN, 1951) has been refuted by the findings of stimulation of cerebral oxygen consumption in vivo by epinephrine and related drugs (KING, SOKOLOFF and WECHSLER, 1952; RICHARDSON, FERGUSON and PATTERSON, 1957). The possibility that the blood-brain barrier limits the penetration of thyroxine into the cerebral tissues has been excluded by studies with 13Flabelled thyroxine which indicate that increased cerebral uptake follows increased circulating levels of thyroxine (FORD and GROSS, 1958~7, b; SOKOLOFF and DURELL, unpublished). In addition to the apparent lack of response to thyroxine, the metabolism of the mature brain manifests a number of other unique features. It normally exhibits a relatively high rate of oxygen consumption which in vivo can be supported only by the utilization of comparably high amounts of carbohydrate (KETY, 1957; SOKOLOFF, 1960). In fact, in vivo the brain utilizes oxygen and glucose in almost stoichiometric amounts, and the respiratory quotient approximates unity and furthermore, the brain fails to take up from the blood any substrate other than glucose in more than insignificant amounts (KETY, 1957; SOKOLOFF, 1960). All these features suggest that protein and lipid turnover are only negligibly reflected in the gross oxidative metabolism of the mature brain as compared to that of carbohydrate. It is noteworthy that of the three tissues, brain, testis, and spleen, in which oxidative metabolism has been reported to be unaffected in hyperthyroidism (GORDON and HEMING, 1944), two, the brain and testis, have a respiratory quotient of approximately one (HIMWICH and NAHUM, 1929; KETY, 1957; SOKOLOFF, 1960). On the other hand, in the immature or developing brain, in which the rates of protein (GAITONDE and RICHTER,
83 citations
TL;DR: The previously reported 3-methylcrotonic acid was shown to be an artefact and is not a diagnostic metabolite for this defect, and the urinary organic acid profile of3-hydroxy-3-methylglutaric aciduria contains excessive amounts of 3- methylglutaconic acid.
79 citations
70 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2020 | 1 |
| 2019 | 1 |
| 2018 | 4 |
| 2017 | 1 |
| 2014 | 2 |
| 2013 | 1 |