Topic
Genkwanin
About: Genkwanin is a research topic. Over the lifetime, 215 publications have been published within this topic receiving 5145 citations. The topic is also known as: 7-methylapigenin & 5,4'-Dihydroxy-7-methoxyflavone.
Papers published on a yearly basis
Papers
TL;DR: The distribution of six compounds with three different polyphenol skeletons in Rosmarinus officinalis suggests that rosemary extracts are excellent antioxidants in both aqueous and lipid systems.
Abstract: The distribution of six compounds with three different polyphenol skeletons have been studied in Rosmarinus officinalis: phenolic diterpenes (carnosic acid, carnosol, and 12-O-methylcarnosic acid), caffeoyl derivatives (rosmarinic acid), and flavones (isoscutellarein 7-O-glucoside and genkwanin), each showing a characteristic behavior and distribution during the vegetative cycle. Only in leaves were all six compounds present, and the highest accumulation rate was related with the young stages of development. Rosmarinic acid showed the highest concentrations of all the polyphenols in all organs. The distribution of this acid in leaves, flowers, and stems suggests that in the first stages of flower growth, levels were due to in situ biosynthesis, and in the last stages, the contribution of transport phenomena was increased. The antioxidant activity of six extracts with different polyphenolic composition was evaluated in aqueous and lipid systems. The results clearly suggest that rosemary extracts are excellent antioxidants in both aqueous and lipid systems.
393 citations
TL;DR: This is the first report of biological activity with several of these antibacterial flavonoids, i.e. apigenin; genkwanin; rhamnocitrin; quercetin-5,3'-dimethylether;rhamnazin, which had a higher anti-inflammatory activity than the positive control mefenamic acid.
313 citations
TL;DR: The antimicrobial activity of stems methanol extract from Daphne gnidium L. gnidium collected from Sardinia was evaluated against 6 strains of standard and clinical isolated gram (+/-) bacteria and two strains of fungi.
183 citations
TL;DR: In this study the in vitro antiplasmodial activities of extracts from Cussonia spicata (Araliaceae), Artemisia afra, Vernonia colorata, V. natalensis (Asteraceae), Parinari curatellifolia (Chrysobalanaceae), Clutia hirsuta, Flueggea virosa, (Euphorbiaceae), Adenia gummifera (Passifloraceae) and Hy
Abstract: In this study the in vitro antiplasmodial activities of extracts from Cussonia spicata (Araliaceae), Artemisia afra, Vernonia colorata, V. natalensis (Asteraceae), Parinari curatellifolia (Chrysobalanaceae), Clutia hirsuta, Flueggea virosa, (Euphorbiaceae), Adenia gummifera (Passifloraceae) and Hymenodictyon floribundum, (Rubiaceae) were evaluated. The lipophilic extracts from the aerial parts of Artemisia afra and Vernonia colorata proved to be the most active against the chloroquine-sensitive strain PoW and against the chloroquine-resistant clone Dd2 of Plasmodium falciparum. Bioassay-guided fractionation of the extract of A. afra yielded seven flavonoids, from which acacetin, genkwanin and 7-methoxyacacetin showed in vitro activity; the IC(50) values ranged from 4.3 microgram/mL to 12.6 microgram/mL. In addition, several sesquiterpene lactones could be obtained from the most active fractions. Whereas eudesmaafraglaucolide proved to be inactive, the guaianolides 1-desoxy-1alpha-peroxy-rupicolin A-8-O-acetate, 1alpha,4alpha-dihydroxybishopsolicepolide and rupicolin A-8-O-acetate revealed in vitro antiplasmodial activity. Evaluation of V. colorata gained four sesquiterpenes 11beta,13-dihydrovernodalin, vernodalol, 11beta,13-dihydrovernolide and 11beta,13,17,18-tetrahydrovernolide, from which the first two constituents exhibited the strongest antiplasmodial activity (IC(50) values: 1.1-4.8 microgram/mL).
175 citations
TL;DR: Fractionation of the chloroformic extracts from Teucrium ramosissimum leaves resulted in the isolation of three flavonoids: genkwanin, cirsimaritin and 4',7-dimethoxy apigenin and one sesquiterpene: β-eudesmol, which exhibited the highest antioxidant activity.
124 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 4 |
| 2020 | 5 |
| 2019 | 9 |
| 2018 | 9 |
| 2017 | 5 |
| 2016 | 11 |