Topic
Gelsemium
About: Gelsemium is a research topic. Over the lifetime, 154 publications have been published within this topic receiving 2519 citations.
Papers published on a yearly basis
Papers
TL;DR: It is evident from the available literature that Gelsemium species possess potential for use as a beneficial therapeutic remedy, however, the analysis of previous pharmacological research suggests that a clear assignment of active molecules and mechanisms of action is remain lacking.
184 citations
TL;DR: A crude alkaloidal fraction from its leaves was isolated by conventional acid-base extraction and showed analgesic and anti-inflammatory effects, and it was postulated that the alkaloids act centrally against GABA action.
182 citations
TL;DR: The overall pattern of results provides evidence that G. sempervirens acts on the emotional reactivity of mice, and that its anxiolytic-like effects are apparent, with a non-linear relationship, even at high dilutions.
Abstract: Introduction
This study was designed to investigate the putative anxiolytic-like activity of ultra-low doses of Gelsemium sempervirens (G. sempervirens), produced according to the homeopathic pharmacopeia.
105 citations
TL;DR: Four new gelsedine-type indole alkaloids were isolated from the leaves of Gelsemium elegans, together with 11 known alkaloid structures determined as 14-acetoxygelsenicine, which showed potent cytotoxic effects.
Abstract: Four new gelsedine-type indole alkaloids (1−4) were isolated from the leaves of Gelsemium elegans, together with 11 known alkaloids. The structures were determined as 14-acetoxygelsenicine (1), 14-acetoxy-15-hydroxygelsenicine (2), 14-hydroxy-19-oxogelsenicine (3), and 14-acetoxygelselegine (4), respectively, by spectroscopic analysis. The cytotoxic effects of 14 Gelsemium alkaloids including two new compounds (1, 2) were evaluated using the A431 human epidermoid carcinoma cell line. Of these, the gelsedine-type alkaloids 14-acetoxygelsenicine (1), 14,15-dihydroxygelsenicine (5), gelsedine (7), and gelsemicine (8) showed potent cytotoxic effects.
103 citations
TL;DR: In this paper, the roots of Gelsemium elegans collected in Thailand resulted in the isolation of the new indole alkaloids, 16-epi-voacarpine, 19-hydroxydihydrogelsevirine, and 19-(Z)-taberpsychine, along with eight known bases.
95 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 5 |
| 2020 | 1 |
| 2019 | 7 |
| 2018 | 4 |
| 2017 | 4 |
| 2016 | 4 |