Topic
Gambit
About: Gambit is a research topic. Over the lifetime, 518 publications have been published within this topic receiving 6300 citations.
Papers published on a yearly basis
Papers
TL;DR: A discussion of the shortcomings of the present system for drug classification is discussed and a "spread sheet" approach to antiarrhythmic action is presented that considers each drug as a unit, with similarities to and dissimilarities from other drugs being highlighted.
Abstract: The Queen's Gambit is an opening move in chess that provides a variety of aggressive options to the player electing it. This report represents a similar gambit (the Sicilian Gambit) on the part of a group of basic and clinical investigators who met in Taormina, Sicily to consider the classification of antiarrhythmic drugs. Paramount to their considerations were 1) dissatisfaction with the options offered by existing classification systems for inspiring and directing research, development, and therapy, 2) the disarray in the field of antiarrhythmic drug development and testing in this post-Cardiac Arrhythmia Suppression Trial (CAST) era, and 3) the desire to provide an operational framework for consideration of antiarrhythmic drugs that will both encourage advancement and have the plasticity to grow as a result of the advances that occur. The multifaceted approach suggested is, like the title of the article, a gambit. It is an opening rather than a compendium and is intended to challenge thought and investigation rather than to resolve issues. The article incorporates first, a discussion of the shortcomings of the present system for drug classification; second, a review of the molecular targets on which drugs act (including channels and receptors); third, a consideration of the mechanisms responsible for arrhythmias, including the identification of "vulnerable parameter" that might be most accessible to drug effect; and finally, clinical considerations with respect to antiarrhythmic drugs. Information relating to the various levels of information is correlated across categories (i.e., clinical arrhythmias, cellular mechanisms, and molecular targets), and a "spread sheet" approach to antiarrhythmic action is presented that considers each drug as a unit, with similarities to and dissimilarities from other drugs being highlighted. A complete reference list for this work would require as many pages as the text itself. For this reason, referencing is selective and incomplete. It is designed, in fact, to provide sufficient background information to give the interested reader a starting frame of reference rather than to recognize the complete body of literature that is the basis for this article.
509 citations
TL;DR: Situations in which the results of the turning gambit may be expected to give realistic predictions of capture or escape are discussed together with physical factors governing the relationship between turning radius and velocity, and the conditions under which the prey might profitably trade higher velocity for a smaller turning radius.
412 citations
TL;DR: This work highlights three future research priorities: systematic theoretical analysis of the evolutionary properties of learning rules; detailed empirical study of how animals learn in nonforaging contexts; and analysis of individual differences in learning rules and their associated fitness consequences.
Abstract: Behavioral ecologists have long been comfortable assuming that genetic architecture does not constrain which phenotypescan evolve (the "phenotypic gambit"). For flexible behavioral traits, however, solutions to adaptive problems are reached not only by genetic evolution but also by behavioral changes within an individual's lifetime, via psychological mechanisms such as learning. Standard optimality approaches ignore these mechanisms, implicitly assuming that they do not constrain the expression of adaptive behavior. This assumption, which we dub the behavioral gambit, is sometimes wrong: evolved psychological mechanisms can prevent animals from behaving optimally in specific situations. To understand the functional basis of behavior, we would do better by considering the underlying mechanisms, rather than the behavioral outcomes they produce, as the target of selection. This change of focus yields new, testable predictions about evolutionary equilibria, the development of behavior, and the properties of cognitive systems. Studies on the evolution of learning rules hint at the potential insights to be gained, but such mechanism-based approaches are underexploited. We highlight three future research priorities: (1) systematic theoretical analysis of the evolutionary properties of learning rules; (2) detailed empirical study of how animals learn in nonforaging contexts;and (3) analysis of individual differences in learning rules and their associated fitness consequences.
279 citations
TL;DR: In this article, a comparison between ANSYS Workbench and Gambit meshing tools for the numerical modeling is performed to summarize a final numerical sequence for the Darrieus rotor performance.
186 citations
1 Jan 1986
TL;DR: Available data appears to support no more than a simple linear proportioning of the two types of motion though a squared weighting, as originally proposed (and which intuitively is more plaus ible) also seems valid.
Abstract: A c r i t e ri o n f o r brain inj ury threshold i s proposed w h i c h , for the f i r s t time, endeavours to take into consideration the combined effects of both t rans l a t ional and rotat ional kinema t i cs. The val i d i t y of the mode l is as s e s s ed by w ay of a review of a l l known head inj u ry data bases in which translational and rotational accelerations have been monitored. Available data appears to support no more than a simple linear proportioning of the two types of motion though a squared weighting, as originally proposed (and which intuitively is more plaus ible) also seems valid.
150 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 30 |
| 2024 | 30 |
| 2023 | 44 |
| 2022 | 64 |
| 2021 | 26 |
| 2020 | 29 |