Topic
Galactosides
About: Galactosides is a research topic. Over the lifetime, 363 publications have been published within this topic receiving 8819 citations.
Papers published on a yearly basis
1 / 2
Papers
TL;DR: Evidence was consistent with the hypothesis that the same membrane carriers were involved in active transport by control cells and facilitated diffusion by poisoned cells, and the most striking finding was that the addition of metabolic inhibitors reduced the KT of exit about two orders of magnitude, whereas the Kt of entrance remained constant.
426 citations
TL;DR: A membrane filter technique was used to study the effect of galactosides and other low molecular weight compounds on the interaction of purified lac repressor and lac operator, finding compounds that function in vivo as inducers of the lac operon are found to inhibit repressor-operator binding in vitro.
287 citations
TL;DR: It is concluded that vicinal galactosyl moieties within a cluster Galactoside are more optimal recognized by the galactose binding sites of the asialoglycoprotein receptor upon proper spacing.
Abstract: High-affinity ligands for the asialoglycoprotein receptor, which is uniquely localized on the parenchymal liver cell and recognizes oligoantennary galactosides, might be utilized as homing device to specifically target drugs or genes to parenchymal liver cells. In the present study, the synthesis of galactose-terminated triantennary glycosides, provided with various spacers between the beta-galactopyranosyl moieties and the branching point of the dendrite, is described. N-[Tris[[(methylthio)methoxy]methyl]methyl]-N alpha-[1-(6- methyladipy)]glycinamide (3b) was glycosylated with monogalactosyl derivatives, containing propanediol or ethylene glycol units as hydrophilic spacer moieties, to yield the corresponding cluster galactosides. To determine the affinity of the cluster galactosides for the asialoglycoprotein receptor, we have performed competition studies of [125I]ASOR binding, a specific ligand for the asialoglycoprotein receptor, to isolated parenchymal cells. The affinity for the asialoglycoprotein receptor significantly increased with increasing spacer length. N-[[[Tris-O-(beta-D-galactopyranosyl)-3,6,9-trioxaunde- canoxy]methoxy]methyl]-N-alpha-[1-(6-methyladipyl)]glycinami de (4e), a cluster galactoside provided with a 20 A spacer, possessed an at least 2000-fold higher affinity for the receptor than N-[[tris-O-(beta-D-galactopyranosyl)methyl]methyl]-N alpha-[1-(6- methyladipyl)]glycinamide (4a), a cluster galactoside lacking the spacer. It is concluded that vicinal galactosyl moieties within a cluster galactoside are more optimal recognized by the galactose binding sites of the asialoglycoprotein receptor upon proper spacing. The most potent galactoside, TG(20A), may constitute an attractive targeting device for the specific delivery of drugs and/or genes to the parenchymal liver cell.
207 citations
TL;DR: This review focuses on updated information about α-galactosides, their chemical structure, biosynthesis, plant physiological functions, occurrence in foods, positive and negative physiological effects in animals, changes during food processing, and their potential application as prebiotics in the food industry.
Abstract: This review focuses on updated information about α-galactosides, their chemical structure, biosynthesis, plant physiological functions, occurrence in foods, positive and negative physiological effe...
172 citations
TL;DR: Two bacterial beta1- 4-galactosyltransferases, NmLgtB and Hp1-4GalT, exhibit promiscuous and complementary acceptor substrate specificity and have been used in an efficient one-pot multienzyme system to synthesize LacNAc, lactose, and their derivatives including those containing negatively charged 6-O-sulfated GlcNAc and C2-substituted Glc NAc or Glc, from monos
161 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 2 |
| 2024 | 6 |
| 2023 | 3 |
| 2022 | 10 |
| 2021 | 4 |
| 2020 | 9 |