Topic
Frei test
About: Frei test is a research topic. Over the lifetime, 42 publications have been published within this topic receiving 223 citations.
Papers
TL;DR: An intradermal skin test, now known as the Frei test, which is characterized by an intrader mal nodule appearing from thirty-six to seventy-two hours after injection into the body, is announced.
Abstract: In 1913 Durand, Nicolas and Favre1differentiated from inguinal adenitis due to chancroid, syphilis and tuberculosis a new venereal disease, which they called subacute inguinal lymphogranulomatosis and which they established as a venereal disease entity. This disease has been variously referred to in the literature as a climatic bubo, tropical bubo, nonvenereal bubo, subacute inguinal periadenitis, fourth venereal disease, strumous bubo of the groin, nontuberculous lymphadenitis, subacute lymphadenitis, malady Nicolas-Favre, hypertrophic bubo and lymphopathia venereum. The primary lesion on the glans penis, in the vagina or elsewhere may be trivial and evanescent and may entirely escape notice. During an incubation period of from ten to thirty days2inguinal adenitis may develop, and this may result in suppuration. In 1925 Frei3announced an intradermal skin test, now known as the Frei test, which is characterized by an intradermal nodule appearing from thirty-six to seventy-two hours after injection into
20 citations
TL;DR: The recent appearance of an article by Strauss and Howardcondemning the use of lymphogranulomatous mouse brain antigen for the routine performance of the Frei test has necessitated the publication of the results with theUse of this material for a period of two years at the New York Hospital.
Abstract: The recent appearance of an article by Strauss and Howard1condemning the use of lymphogranulomatous mouse brain antigen for the routine performance of the Frei test has necessitated the publication of our results with the use of this material for a period of two years at the New York Hospital. Since May 1934, 595 tests have been made with mouse brain materials in an attempt to establish the efficacy of lymphogranulomatous mouse brain antigen for Frei testing. The tests included those performed with lymphogranulomatous mouse brain antigen, both our own (New York Hospital) and commercial, in patients infected with lymphogranuloma inguinale and control tests which were carried out with normal mouse brain antigen in the same subjects and with normal mouse brain and lymphogranulomatous mouse brain antigens in individuals who have never had the disease. In Strauss and Howard's paper the only results that are strictly comparable with ours
19 citations
TL;DR: Lygranum antigen is superior to mouse brain antigen in sensitivity and specificity in the performance of the Frei test for lymphogranuloma venereum and mouse brain control in producing non-specific reactions in only 2 of 35 persons.
Abstract: ConclusionsLygranum antigen is superior to mouse brain antigen in sensitivity and specificity in the performance of the Frei test for lymphogranuloma venereum. Lygranum control is superior also to mouse brain control in producing non-specific reactions in only 2 of 35 persons as compared with 28 of 36 in the case of mouse brain control. In the group of 36 tested only one individual showed a reaction which could be regarded as resulting from hypersensitivity to chick material.
18 citations
TL;DR: Since Frei 1 demonstrated that an antigen, made from sterile pus aspirated from previously unruptured abscesses, produced a reaction in patients with lymphogranuloma inguinale when injected intradermally, many attempts have been made to find other reliable sources for this antigen.
Abstract: Since Frei 1 demonstrated that an antigen, made from sterile pus aspirated from previously unruptured abscesses, produced a reaction in patients with lymphogranuloma inguinale when injected intradermally, many attempts have been made to find other reliable sources for this antigen. Satisfactory antigens have been made by grinding up infected glands and periglandular tissues, and there have been reports of antigens made from pus from rectal fistulas occurring in patients with the late manifestations of this disease. This reaction is an important aid in the diagnosis of lymphogranuloma inguinale. It is now well known that mice can be infected with lymphogranuloma inguinale by intracerebral inoculation of material from early cases and that the infection can be passed through several generations. One of the means of determining whether an animal has been infected with the disease is by making an antigen from the brain tissue and testing this on patients known to
15 citations
TL;DR: In this article, the appearance of the corneal lesions was identical in each patient, and the lesions were also the same as that reported by Meyer and Reber in 1940 in 1 patient, who was observed by one of us (H. G. S.) at that time.
Abstract: I. INTRODUCTION Five patients having keratitis probably pathognomonic of lymphogranuloma venereum are herewith reported. The appearance of the corneal lesions was identical in each patient. The lesions were also the same as that reported by Meyer and Reber 1 in 1940 in 1 patient, who was observed by one of us (H. G. S.) at that time. Ocular involvement is one of many manifestations of lymphogranuloma venereum, which is a widespread systemic disease. Inguinal involvement has been recognized for over a century, but it was not until the work of Durand, Nicolas and Favre 2 in 1913 that the disease was established as a specific entity. Knowledge of the complex nature of the disease and the numerous lesions produced by it awaited discovery of the Frei test 3 (1925) and the means of isolating the specific virus by Hellerstrom and Wassen 4 (1930). II. INCIDENCE OF LYMPHOGRANULOMA VENEREUM The distribution
12 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 1972 | 1 |
| 1965 | 1 |
| 1954 | 1 |
| 1952 | 1 |
| 1949 | 1 |
| 1947 | 1 |