Topic
FOX proteins
About: FOX proteins is a research topic. Over the lifetime, 109 publications have been published within this topic receiving 13541 citations. The topic is also known as: FoxO & Forkhead Transcription Factors.
Papers published on a yearly basis
Papers
TL;DR: The winged helix/forkhead class of transcription factors is characterized by a 100-amino-acid, monomeric DNAbinding domain, which folds into a variant of the helix–turn–helix motif and is made up of three a helices and two characteristic large loops, or “wings.”
Abstract: The winged helix/forkhead class of transcription factors is characterized by a 100-amino-acid, monomeric DNAbinding domain. The structure of the DNA-binding domain of one of the class members, hepatocyte nuclear factor 3 g (HNF3g), in a complex with a DNA target has been solved (Clark et al. 1993). The DNA-binding domain folds into a variant of the helix–turn–helix motif and is made up of three a helices and two characteristic large loops, or “wings.” Therefore, the DNA-binding motif has been named the winged helix DNA-binding domain. Over the past 9 years since the identification of the first member of this class, the Drosophila melanogaster gene Fork head, >100 members of this gene family have been identified (for review, see Kaufmann and Knöchel 1996) in species ranging from yeast to human. The rapid accumulation of sequences by many different laboratories has led to the use of multiple names and classification systems, making it very difficult to follow the literature and to name newly characterized winged helix/ forkhead transcription factors. This problem was recognized and discussed at the first International Meeting on Forkhead/Winged Helix Proteins, held in La Jolla, California, in November 1998. At that time a proposal was developed to standardize the nomenclature for these proteins. Fox (Forkhead box) was adopted as the unified symbol for all chordate winged helix/forkhead transcription factors. A winged helix/forkhead nomenclature committee was elected to implement this proposal, in consultation with the community at large. This final proposal has been endorsed by >20 scientists as well as the Human and Mouse Gene Nomenclature Committees.
1,210 citations
TL;DR: The evidence that the deregulation of Fox family transcription factors has a crucial role in the development and progression of cancer is discussed, and the emerging role of Fox proteins as direct and indirect targets for therapeutic intervention, as well as biomarkers for predicting and monitoring treatment responses are evaluated.
Abstract: Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional regulators, which control a wide spectrum of biological processes. As a consequence, a loss or gain of Fox function can alter cell fate and promote tumorigenesis as well as cancer progression. Here we discuss the evidence that the deregulation of Fox family transcription factors has a crucial role in the development and progression of cancer, and evaluate the emerging role of Fox proteins as direct and indirect targets for therapeutic intervention, as well as biomarkers for predicting and monitoring treatment responses.
1,099 citations
TL;DR: The MADS-box family of transcription factors has been defined on the basis of primary sequence similarity amongst numerous proteins from a diverse range of eukaryotic organisms including yeasts, plants, insects, amphibians and mammals and the name refers to four of the originally identified members: MCM1, AG, DEFA and SRF.
Abstract: The MADS-box family of transcription factors has been defined on the basis of primary sequence similarity amongst numerous proteins from a diverse range of eukaryotic organisms including yeasts, plants, insects, amphibians and mammals. The MADS-box is a conserved motif found within the DNA-binding domains of these proteins and the name refers to four of the originally identified members: MCM1, AG, DEFA and SRF. Several proteins within this family have significant biological roles. For example, the human serum-response factor (SRF) is involved in co-ordinating transcription of the protooncogene c-fos, whilst MCM1 is central to the transcriptional control of cell-type specific genes and the pheromone response in the yeast Saccharomyces cerevisiae. The RSRF/MEF2 proteins comprise a sub-family of this class of transcription factors which are key components in muscle-specific gene regulation. Moreover, in plants, MADS-box proteins such as AG, DEFA and GLO play fundamental roles during flower development. The MADS-box is a contiguous conserved sequence of 56 amino acids, of which 9 are identical in all family members described so far. Several members have been shown to form dimers and consequently two functional regions within the MADS-box have been defined. The N-terminal half is the major determinant of DNA-binding specificity whilst the C-terminal half is necessary for dimerisation. This organisation allows the potential formation of numerous proteins, with subtly different DNA-binding specificities, from a limited number of genes by heterodimerisation between different MADS-box proteins. The majority of MADS-box proteins bind similar sites based on the consensus sequence CC(A/T)6GG although each protein apparently possesses a distinct binding specificity. Moreover, several MADS-box proteins specifically recruit other transcription factors into multi-component regulatory complexes. Such interactions with other proteins appears to be a common theme within this family and play a pivotal role in the regulation of target genes.
891 citations
TL;DR: It is shown that HNF-3 beta has an essential role in the development of axial mesoderm in mouse embryos and marked defects in the organization of somites and neural tube that may result from the absence of the notochord.
841 citations
TL;DR: The purpose of this review is to summarize the accumulating amount of data on structure, expression and function of fork head/HNF-3-related transcription factors.
709 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 5 |
| 2020 | 1 |
| 2019 | 3 |
| 2018 | 4 |
| 2017 | 5 |
| 2016 | 4 |