Topic
Forebrain morphogenesis
About: Forebrain morphogenesis is a research topic. Over the lifetime, 30 publications have been published within this topic receiving 1143 citations.
Papers
TL;DR: It is shown that CPG15 overexpression in vivo expands the progenitor pool by preventing apoptosis, resulting in an enlarged, indented cortical plate and cellular heterotopias within the ventricular zone, similar to the phenotypes of mutant mice with supernumerary forebrain progenitors.
Abstract: The balance between proliferation and apoptosis is critical for proper development of the nervous system Yet, little is known about molecules that regulate apoptosis of proliferative neurons Here we identify a soluble, secreted form of CPG15 expressed in embryonic rat brain regions undergoing rapid proliferation and apoptosis, and show that it protects cultured cortical neurons from apoptosis by preventing activation of caspase 3 Using a lentivirus-delivered small hairpin RNA, we demonstrate that endogenous CPG15 is essential for the survival of undifferentiated cortical progenitors in vitro and in vivo We further show that CPG15 overexpression in vivo expands the progenitor pool by preventing apoptosis, resulting in an enlarged, indented cortical plate and cellular heterotopias within the ventricular zone, similar to the phenotypes of mutant mice with supernumerary forebrain progenitors CPG15 expressed during mammalian forebrain morphogenesis may help balance neuronal number by countering apoptosis in specific neuroblasts subpopulations, thus influencing final brain size and shape
130 citations
TL;DR: This study shows that double Raldh2/Raldh3 mouse mutants have a more severe phenotype in the craniofacial region than single null mutants, and finds that retinoids act in maintaining the correct position of anterior and dorsal boundaries in the forebrain by modulating FGF8 anteriorly and WNT signaling dorsally.
110 citations
TL;DR: In the adult mouse, ml and m2 receptor immunoreactivity displayed complementary staining patterns in most forebrain areas with m4 sharing simiarities in pattern with both ml andm2, thus suggesting distinct roles for the receptor subtypes in ontogenetic events.
Abstract: Cholinergic mechanisms are involved in the regulation of developmental events in the nervous system. Muscarinic cholinergic receptors are thought to be the predominant mediator of cholinergic neurotransmission in the forebrain; however, their developmental role is less well understood. The present study takes advantage of subtype-specific antibodies to muscarinic receptor proteins to investigate the cellular localization of the subtypes in developing mouse forebrain. Receptor protein expression wag assessed between postnatal day (PND) 5 and adulthood by immunocytochemical methods with antibodies to ml, m2, and m4 receptors, the most abundant subtypes in rodent brain. We have found dramatic developmental changes in the distribution of all three receptors. In the adult mouse, ml and m2 receptor immunoreactivity displayed complementary staining patterns in most forebrain areas with m4 sharing simiarities in pattern with both ml and m2. Furthermore, each receptor was expressed transiently in gray matter areas or fiber bundles at various developmental stages. The m4 receptor was also expressed in developing blood vessels. Such transient immunoreactivity was usually associated with times and areas of dynamic morphogenesis, thus suggesting distinct roles for the receptor subtypes in ontogenetic events. © 1995 Wiley-Liss, Inc.
57 citations
National Institutes of Health1, Erasmus University Rotterdam2, University of Pittsburgh3, University Medical Center Groningen4, University of Washington5, University of Wisconsin-Madison6, Cleveland Clinic7, Boston Children's Hospital8, Texas Scottish Rite Hospital for Children9, University of Texas Southwestern Medical Center10, University of Sheffield11, Koç University12, University of Pennsylvania13, Children's Hospital of Philadelphia14
TL;DR: Findings show the cohesin complex as an important regulator of median forebrain development and X-linked inheritance patterns in holoprosencephaly.
Abstract: Marked by incomplete division of the embryonic forebrain, holoprosencephaly is one of the most common human developmental disorders. Despite decades of phenotype-driven research, 80-90% of aneuploidy-negative holoprosencephaly individuals with a probable genetic aetiology do not have a genetic diagnosis. Here we report holoprosencephaly associated with variants in the two X-linked cohesin complex genes, STAG2 and SMC1A, with loss-of-function variants in 10 individuals and a missense variant in one. Additionally, we report four individuals with variants in the cohesin complex genes that are not X-linked, SMC3 and RAD21. Using whole mount in situ hybridization, we show that STAG2 and SMC1A are expressed in the prosencephalic neural folds during primary neurulation in the mouse, consistent with forebrain morphogenesis and holoprosencephaly pathogenesis. Finally, we found that shRNA knockdown of STAG2 and SMC1A causes aberrant expression of HPE-associated genes ZIC2, GLI2, SMAD3 and FGFR1 in human neural stem cells. These findings show the cohesin complex as an important regulator of median forebrain development and X-linked inheritance patterns in holoprosencephaly.
50 citations
1 Jan 2006
TL;DR: Pioneer Neurons and Interneurons in the Developing Subplate: Molecular Markers, Cell Birthdays, and Neurotransmitters.
Abstract: Pioneer Neurons and Interneurons in the Developing Subplate: Molecular Markers, Cell Birthdays, and Neurotransmitters.- Dual Roles of Transcription Factors in Forebrain Morphogenesis and Development of Axonal Pathways.- Subcortical and Neocortical Guidance of Area-specific Thalamic Innervation.- The Earliest Thalamocortical Interactions.- Molecular Basis for the Formation of Lamina-Specific Thalamocortical Projection.- Role of Citron K in the Development of Cerebral Cortex.- The Absence of Layer 4 Dramatically Alters Cortical Development in Ferret Somatosensory Cortex.- Influence of Thalamocortical Activity on Sensory Cortical Development and Plasticity.- Pathways to Barrel Development.- Patterning of the Somatosensory Maps with NMDA Receptors.- Presynaptic Mechanisms Controlling Axon Terminal Remodeling in the Thalamocortical and Retinogeniculate Systems.- Cellular Mechanisms Underlying the Remodeling of Retinogeniculate Connections.- A Model for Synaptic Refinement in Visual Thalamus.- Making and Breaking Eye-specific Projections to the Lateral Geniculate Nucleus.- LTD as a Mechanism for Map Plasticity in Rat Barrel Cortex.- High-Field (9.4T) Magnetic Resonance Imaging in Squirrel Monkey.
39 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
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| 2021 | 1 |
| 2020 | 1 |
| 2019 | 3 |
| 2018 | 3 |
| 2017 | 4 |
| 2016 | 1 |