Topic
Forebrain
About: Forebrain is a research topic. Over the lifetime, 7022 publications have been published within this topic receiving 456096 citations. The topic is also known as: forebrain.
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Papers
Book•
1 Jan 1985
TL;DR: The present work focuses on the development of brain Stem Systems Involved in the Blink Reflex, Feeding Mechanisms, and Micturition of the Spinal Cord, which are involved in the selection of somatic and emotional components of the Motor System in Mammals.
Abstract: Vasculature O.U. Scremin, Cerebral Vascular System. Spinal Cord and Peripheral Nervous System C. Molander and G. Grant, Spinal Cord Cytoarchitecture. A. Ribeiro-da-Silva, Substantia Gelantinosa of Spinal Cord. G. Grant, Primary Afferent Projections to the Spinal Cord. D.J. Tracey, Ascending and Descending Pathways in the Spinal Cord. G. Gabella, Autonomic Nervous System. Brainstem and Cerebellum C.B. Saper, CentralAutonomic System. G. Holstege, The Basic, Somatic, and Emotional Components of the Motor System in Mammals. B.E. Jones, Reticular Formation: Cytoarchitecture, Transmitters, and Projections. A.J. Beitz, Periaqueductal Gray. G. Aston-Jones, M.T. Shipley, and R. Grzanna, The Locus Coeruleus, A5 and A7 Noradrenergic Cell Groups. J.H. Fallon and S.E. Loughlin, Substantia Nigra. J.B. Travers, Oromotor Nuclei. G. Holstege, B.F.M. Blok, and G.J. ter Horst, Brain Stem Systems Involved in the Blink Reflex, Feeding Mechanisms, and Micturition. T.J.H. Ruigrok and F. Cella, Precerebellar Nuclei and Red Nucleus. J. Voogd, Cerebellum. Forebrain R.B. Simerly, Anatomical Substrates of Hypothalamic Integration. W.E. Armstrong, Hypothalamic Supraoptic and Paraventricular Nuclei. B.J. Oldfield and M.J. McKinley, Circumventricular Organs. R.L. Jakab and C. Leranth, Septum. D.G. Amaral and M.P. Witter, Hippocampal Formation. G.F. Alheid, J.S. de Olmos, and C.A. Beltramino, Amygdala and Extended Amygdala. L. Heimer, D.S. Zahm, and G.F. Alheid, Basal Ganglia. J.L. Price, Thalamus. K. Zilles and A. Wree, Cortex: Areal and Laminar Structure. Sensory Systems D.J. Tracey and P.M.E. Waite, Somatosensory System. P.M.E. Waite and D.J. Tracey, Trigeminal Sensory System. W.D. Willis, K.N. Westlund, and S.M. Carlton, Pain. R. Norgren, Gustatory System. J.A. Rubertone, W.R. Mehler, and J. Voogd, The Vestibular Nuclear Complex. W.R. Webster, Auditory System. A.J. Sefton and B. Dreher, Visual System. M.T. Shipley, J.H. McLean, and M. Ennis, Olfactory System. Neurotransmitters G. Halliday, A. Harding, and G. Paxinos, Serotonin and Tachykinin Systems. S.E. Loughlin, F.M. Leslie, and J.H. Fallon, Endogenous Opioid Systems. L.L. Butcher, Cholinergic Neurons and Networks. O.P. Ottersen, O.P. Hjelle, K.K. Osen, and J.H. Laake, Amino Acid Transmitters. Development S.A. Bayer and J. Altman, Neurogenesis and Neuronal Migration. S.A. Bayer and J. Altman, Principles of Neurogenesis, Neuronal Migration, and Neural Circuit Formation. Subject Index.
4,507 citations
TL;DR: The hypothesis states that the basal ganglia do not generate movements, and when voluntary movement is generated by cerebral cortical and cerebellar mechanisms, the basal Ganglia act broadly to inhibit competing motor mechanisms that would otherwise interfere with the desired movement.
2,649 citations
TL;DR: Parkinsons disease is a multisystem disorder that involves only a few predisposed nerve cell types in specific regions of the human nervous system as discussed by the authors, where the intracerebral formation of abnormal proteinaceous Lewy bodies and Lewy neurites advances in a topographically predictable sequence.
Abstract: The synucleinopathy, idiopathic Parkinson's disease, is a multisystem disorder that involves only a few predisposed nerve cell types in specific regions of the human nervous system. The intracerebral formation of abnormal proteinaceous Lewy bodies and Lewy neurites begins at defined induction sites and advances in a topographically predictable sequence. As the disease progresses, components of the autonomic, limbic, and somatomotor systems become particularly badly damaged. During presymptomatic stages 1-2, inclusion body pathology is confined to the medulla oblongata/pontine tegmentum and olfactory bulb/anterior olfactory nucleus. In stages 3-4, the substantia nigra and other nuclear grays of the midbrain and forebrain become the focus of initially slight and, then, severe pathological changes. At this point, most individuals probably cross the threshold to the symptomatic phase of the illness. In the end-stages 5-6, the process enters the mature neocortex, and the disease manifests itself in all of its clinical dimensions.
2,473 citations
TL;DR: The functional and neuroanatomical data obtained suggest that disease processes involving inappropriate stress control involve dysfunction of processive stress pathways.
2,362 citations
TL;DR: MSCs are capable of producing differentiated progeny of a different dermal origin after implantation into neonatal mouse brains and are potentially useful as vectors for treating a variety of central nervous system disorders.
Abstract: Stem cells are a valuable resource for treating disease, but limited access to stem cells from tissues such as brain restricts their utility. Here, we injected marrow stromal cells (MSCs) into the lateral ventricle of neonatal mice and asked whether these multipotential mesenchymal progenitors from bone marrow can adopt neural cell fates when exposed to the brain microenvironment. By 12 days postinjection, MSCs migrated throughout the forebrain and cerebellum without disruption to the host brain architecture. Some MSCs within the striatum and the molecular layer of the hippocampus expressed glial fibrillary acidic protein and, therefore, differentiated into mature astrocytes. MSCs also populated neuron rich regions including the Islands of Calleja, the olfactory bulb, and the internal granular layer of the cerebellum. A large number of MSCs also were found within the external granular layer of the cerebellum. In addition, neurofilament positive donor cells were found within the reticular formation of the brain stem, suggesting that MSCs also may have differentiated into neurons. Therefore, MSCs are capable of producing differentiated progeny of a different dermal origin after implantation into neonatal mouse brains. These results suggest that MSCs are potentially useful as vectors for treating a variety of central nervous system disorders.
1,836 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 124 |
| 2024 | 192 |
| 2023 | 219 |
| 2022 | 371 |
| 2021 | 183 |
| 2020 | 193 |