Topic
Focal Pattern
About: Focal Pattern is a research topic. Over the lifetime, 51 publications have been published within this topic receiving 394 citations.
Papers published on a yearly basis
Papers
TL;DR: It is suggested that the focal accumulation of phosphorylated neurofilament proteins within anterior horn cells in familial ALS is characteristic of familial ALS, although it may not be specific to the entity.
Abstract: Distribution of phosphorylated neurofilament proteins within anterior horn cells in three cases of familial and six cases of sporadic amyotrophic lateral sclerosis (ALS) and ten control cases were investigated by using a monoclonal antibody. Two distinct staining patterns of perikarya were observed; (1) homogeneous pattern; either the entire or a part of the perikaryon was immunostained homogeneously (homogeneously diffuse or partial pattern); (2) focal pattern: perikarya contained very distinct, inclusion-like focal accumulation of immunoreactive products of various morphologies such as round, ring-shaped, cord-like, tube-like and more irregular shapes. The homogeneous pattern was found in all three groups but was most common in sporadic ALS. On the other hand, the focal pattern was seen almost exclusively in familial ALS. The focal accumulation of neurofilaments appears at least in part to be related to the Lewy body-like hyaline inclusion which is known to contain neurofilaments. In addition, cord-like swellings of neurites in familial ALS also showed focal neurofilament accumulation. These observations suggest that the focal accumulation of phosphorylated neurofilaments is characteristic of familial ALS, although it may not be specific to the entity. The pathological process(es) producing the neurofilamentous abnormality may play an important role in anterior horn cell degeneration in familial ALS.
87 citations
TL;DR: A mathematical model is developed to examine whether cell adhesion can explain the formation of the zebrafish mosaic, and whether the movement of differentiated cells is responsible for generating the pattern, and that the movement rate is modified bycell adhesion.
36 citations
TL;DR: A Radiomics approach improves radiological evaluation of focal and diffuse pattern of MM on CT, and could help radiologists in differentiating diffuse from focal patterns on CT.
33 citations
TL;DR: It is postulated that the appearance of a focal burst-suppression pattern during a thiopental fast activation test implies the presence of underlying structural abnormality.
30 citations
TL;DR: Results suggest that, in children with chronic hepatitis B, the diffuse HBcAg pattern in the liver might reflect an earlier phase of infection, and in HBeAg positive cases the focal HBc Ag pattern may represent a prognostic marker of short-term favourable evolution of the disease.
Abstract: During a prospective follow-up study of 65 children with chronic hepatitis B, the HBcAg expression pattern in the liver was investigated, by immunofluorescence, in relation to biochemical and histological features and to the evolution of the disease. HBcAg was detected in 50 (77%) cases, with a diffuse pattern of distribution (more than 60% positive nuclei) in 20 cases, and with a focal pattern (less than 40% positive nuclei) in 30 cases. The diffuse pattern significantly prevailed in younger children, while the focal pattern was more frequent in children beyond 10 years of age. Transaminase levels were higher and histological features of activity were more frequent in patients with the focal pattern than in those with a diffuse pattern. Twenty-five hepatitis B e antigen (HBeAg) positive children, all initially HBcAg positive, were followed prospectively for 24 months. Seroconversion to anti-HBe, with subsequent normalization of transaminases, occurred in 72% of cases with a focal pattern, but only in 21% of those with a diffuse HBcAg pattern. In four patients transition from the diffuse to the focal pattern was observed during follow-up. These results suggest that, in children with chronic hepatitis B, the diffuse HBcAg pattern in the liver might reflect an earlier phase of infection. In HBeAg positive cases the focal HBcAg pattern may represent a prognostic marker of short-term favourable evolution of the disease.
19 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 2 |
| 2019 | 2 |
| 2018 | 3 |
| 2017 | 3 |
| 2016 | 3 |
| 2015 | 3 |