Topic
Fleischer ring
About: Fleischer ring is a research topic. Over the lifetime, 21 publications have been published within this topic receiving 250 citations.
Papers
TL;DR: In this retrospective study, approximately 20% of eyes with suspected keratoconus progressed to true keratconus in 6 years, and these eyes had presented greater asymmetry and regular astigmatism at the initial examination.
Abstract: Aims: To examine the incidence of progression of suspected keratoconus to true keratoconus and compare quantitative descriptors of corneal topography between eyes with and without progression. Methods: 34 eyes with suspected keratoconus were retrospectively reviewed in 34 patients. Their age at the initial examination was 13 to 40 years (24.1 (7.5), mean (SD)), and the follow-up periods ranged from 3 to 10 years (6.0 (2.2) years). Suspected keratoconus was defined as the fellow eye of a clinically apparent keratoconus but that had no slit-lamp signs of keratoconus (Fleischer ring, Vogt striae and Munson sign) with a best spectacle-corrected visual acuity of 20/20 or better. Eyes were monitored for the progression of apparent slit-lamp findings of keratoconus during the follow-up period. Using a Fourier analysis of the corneal topography data, regular astigmatism, asymmetry component and higher-order irregularity component were calculated in the central 3 mm zone. Quantitative descriptors of corneal topography were compared between eyes which progressed to true keratoconus and those which did not. Results: Five eyes (14.7%) progressed to apparent keratoconus from suspected keratoconus (progression group), and 29 eyes did not (non-progression group). On average, it took 5.2 years for the eyes to develop apparent slit-lamp findings of keratoconus. The cumulative incidence of progression by Kaplan–Meier analysis was 21.5% in 6 years. The asymmetry component and regular astigmatism by Fourier analysis at the initial examination were significantly larger in the progression group than in the non-progression group. Conclusion: In our retrospective study, approximately 20% of eyes with suspected keratoconus progressed to true keratoconus in 6 years, and these eyes had presented greater asymmetry and regular astigmatism at the initial examination.
47 citations
TL;DR: The Fleischer ring of keratoconus was studied with the transmission electron microscope in four corneal buttons and ferritin particles were observed in the cytoplasm of some macrophages and in conjunctival stroma.
Abstract: • The Fleischer ring of keratoconus was studied with the transmission electron microscope in four corneal buttons. The ring was characterized by accumulations of ferritin particles in the widened intercellular spaces and/or in the cytoplasmic vacuoles of the corneal epithelium. Both changes were prominent in basal layers in three cases; in one case, ferritin-containing vacuoles were noted in wing cell layers. Ferritin particles were also scattered over the corneal epithelium in all cases. For comparison, normal human corneas and conjunctivas were studied. Ferritin particles were scattered over the corneal epithelium and throughout the basal cells of the conjunctiva. They were not found in corneal stroma or endothelium. In conjunctival stroma, numerous ferritin particles were observed in the cytoplasm of some macrophages. Possible origin of these particles and the cause of their deposition are discussed.
32 citations
TL;DR: Biomicroscopic examination revealed a corneal epithelial iron ring around the central keratectasia on both corneas that was similar to the iron deposits of the Fleischer ring of keratoconus.
Abstract: A 23-year-old woman had bilateral myopic laser in situ keratomileusis (LASIK). Two months postoperatively, she reported decreased visual acuity. Biomicroscopic examination revealed a corneal epithelial iron ring around the central keratectasia on both corneas. The appearance of the ring pattern was similar to the iron deposits of the Fleischer ring of keratoconus.
29 citations
TL;DR: Surface epithelial cells in this disorder were elongated and contained increased numbers of dark cells in more severe cases, and Invading fibrovascular tissue was identified in superficial pannus.
22 citations
TL;DR: In this paper, a 37-year-old woman had bilateral hyperopic laser in situ keratomileusis (LASIK) and six months postoperatively, an epithelial pigmentation ring pattern was identified on both corneas.
Abstract: A 37-year-old woman had bilateral hyperopic laser in situ keratomileusis (LASIK). Six months postoperatively, an epithelial pigmentation ring pattern was identified on both corneas. The appearance of the ring pattern was similar to the iron deposits of the Fleischer ring of keratoconus. While corneal iron deposits in various patterns have been reported after other forms of ocular therapeutic and refractive surgery, this is the first report of the association between hyperopic LASIK and a corneal iron line, which we have called the “pseudo-Fleischer ring.”
20 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 1 |
| 2020 | 1 |
| 2018 | 1 |
| 2015 | 2 |
| 2014 | 2 |
| 2013 | 1 |