TL;DR: Investigation of extracts of FISSistigma balansae and Fissistigma oldhamii resulted in the isolation of 11 aristolactams-stigmalactam and two dioxoaporphines, noraristolodione (12) and norcepharadione B (13).
Abstract: Investigation of extracts of Fissistigma balansae and Fissistigma oldhamii resulted in the isolation of 11 aristolactams-stigmalactam (1), piperolactam A (2), piperolactam C (3), aristolactam AII (4), aristolactam AIIIa (5), aristolactam BII (6), aristolactam BIII (7), aristolactam FII (8), goniothalactam (9), enterocarpam I (10), and velutinam (11)-as well as two dioxoaporphines, noraristolodione (12) and norcepharadione B (13). The new compound 1 was identified by spectral data interpretation. Compounds 1-13 were subjected to antiplatelet aggregation testing.
TL;DR: In this paper, the basic fractions from Formosan Fissistigma glaucescens, F. oldhamii and Goniothalamus amuyon were separated, and one quaternary phenanthrene alkaloid, N -methylatherosperminium (N -methyl-threshold), along with the known alkaloids, (−)-discretamine (1), (−)-tetrahydropalmatine (2), palmatine(3), asimilobine(4 ), (−)-asocibine(5),
TL;DR: Bioassay-guided fractionation of an ethyl acetate extract of Fissistigma lanuginosum led to the isolation of the known chalcone pedicin, which inhibited tubulin assembly into microtubules (IC50 value of 300 microM), and two new condensed chalcones were obtained from the same EtOAc fraction.
Abstract: Bioassay-guided fractionation of an ethyl acetate extract of Fissistigma lanuginosum led to the isolation of the known chalcone pedicin [1], which inhibited tubulin assembly into microtubules (IC50 value of 300 microM). From the same EtOAc fraction, two new condensed chalcones, fissistin [2] and isofissistin [3], which showed cytotoxicity against KB cells, were also obtained, together with the inactive dihydropedicin [4] and 6,7-dimethoxy-5,8-dihydroxyflavone [5]. In addition, the aminoquinones 6, 8, and 9 were isolated from the alkaloid extract. These compounds were artifacts, prepared by treatment of 1, 4, and 2, respectively, with NH4OH. The structures of the new compounds were elucidated by spectral methods, especially 2D nmr.
TL;DR: A list of the Annonaceae taxa indigenous to the Asia-Pacific Region is presented, including full synonymy and typification with an outline of the geographic distribution, and a number of nomenclatural changes are made.
Abstract: A list of the Annonaceae taxa indigenous to the Asia-Pacific Region (including Australia) is presented, including full synonymy and typification with an outline of the geographic distribution. Some 11
TL;DR: Chromatography of the ethanolic extracts from the twigs of Fissistigma balansae led to the isolation of a new protoberberine alkaloid, fissisaine, along with four known protoberbery alkaloids thaipetaline, kikemanine, columbamine and dehydrodiscretamine.