Topic
Fibrinogen complex
About: Fibrinogen complex is a research topic. Over the lifetime, 35 publications have been published within this topic receiving 1182 citations.
Papers
TL;DR: It is demonstrated that fibrin gels could be used as a carrier matrix for controlled release of bioactive TGF-beta1 by adjusting the concentrations of FC and thrombin in the gels.
Abstract: This study analyzed the ability of fibrin gels to deliver added recombinant transforming growth factor beta-1 (TGF-β1) in a controlled manner and biologically active form. First, the effects of the amount of TGF-β1 on the release kinetics were analyzed using a single fibrin gel formulation (fibrinogen complex (FC) at 25 mg/mL, thrombin at 2 IU/mL). Then, the effects of FC and thrombin concentrations were analyzed. Finally, to test the biological activity of the released TGF-β1 from the gels, medium supernatants taken from gels at day 3 were used as culture medium for human mesenchymal stem cell (HMSC) monolayers. Cell proliferation was analyzed after staining with calcein dye, and changes in cell morphology were observed under fluorescence microscopy at days 1, 4, and 7. At day 7, HMSC chondrogenic differentiation was assessed by Alcian Blue staining and osteogenic differentiation by alkaline phosphatase activity and Alizarin Red staining. Results showed that TGF-β1 added to fibrin gels was gradually rele...
89 citations
Patent•
4 Sep 1992TL;DR: In this article, a composition which, upon reacting with thrombin, functions as a fibrin sealant and is characterized as devoid of infectious agents such as bacteria or viruses and contains no protease inhibitors or other non-human proteins is presented.
Abstract: A composition which, upon reacting with thrombin, functions as a fibrin sealant and is characterized as devoid of infectious agents such as bacteria or viruses and contains no protease inhibitors or other non-human proteins. Also, described is a method for producing the composition.
88 citations
TL;DR: The idea that environmental contaminants such as atrazine compromise important gene pathways during frog development that may, ultimately, be relevant to global amphibian decline is supported.
67 citations
Patent•
8 Jul 1988TL;DR: A polypeptide analog capable of immunoligically mimicking a linear hGPIIb antigenic determinant expressed when platelet-associated GPIIb-IIIa binds fibrinogen is disclosed.
Abstract: A polypeptide analog capable of immunoligically mimicking a linear hGPIIb antigenic determinant expressed when platelet-associated GPIIb-IIIa binds fibrinogen is disclosed. An antibody that immunoreacts with the polypeptide and hGPIIb when hGPIIb is present as a platelet-associated GPIIb-IIIa/fibrinogen complex is also disclosed. Further disclosed are diagnostic systems and methods for assaying fibrinogen-bound platelets in a vascular fluid sample using the polypeptides and/or antibodies of the invention.
62 citations
TL;DR: Fibrin glue was applied on 6-mm-diameter circular full-thickness wounds in homozygous, genetically diabetic mice and showed delayed wound closure as compared to paired control wounds, and the application of an adherent semipermeable dressing over the wound per se resulted in delayed woundclosure.
42 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 3 |
| 2020 | 1 |
| 2016 | 1 |
| 2015 | 1 |
| 2014 | 1 |
| 2013 | 1 |