Topic
FADS2
About: FADS2 is a research topic. Over the lifetime, 421 publications have been published within this topic receiving 16415 citations. The topic is also known as: acyl-CoA 6-desaturase & delta-6-desaturase.
Papers published on a yearly basis
Papers
TL;DR: Delta-6 and Δ5 desaturases are required for the synthesis of highly unsaturated fatty acids (HUFAs), which are mainly esterified into phospholipids and contribute to maintaining membrane fluidity, and may be required for cold tolerance in plants and fish.
Abstract: ▪ Abstract Fatty acid desaturases introduce a double bond in a specific position of long-chain fatty acids, and are conserved across kingdoms. Degree of unsaturation of fatty acids affects physical properties of membrane phospholipids and stored triglycerides. In addition, metabolites of polyunsaturated fatty acids are used as signaling molecules in many organisms. Three desaturases, Δ9, Δ6, and Δ5, are present in humans. Delta-9 catalyzes synthesis of monounsaturated fatty acids. Oleic acid, a main product of Δ9 desaturase, is the major fatty acid in mammalian adipose triglycerides, and is also used for phospholipid and cholesteryl ester synthesis. Delta-6 and Δ5 desaturases are required for the synthesis of highly unsaturated fatty acids (HUFAs), which are mainly esterified into phospholipids and contribute to maintaining membrane fluidity. While HUFAs may be required for cold tolerance in plants and fish, the primary role of HUFAs in mammals is cell signaling. Arachidonic acid is required as substrates...
1,045 citations
TL;DR: The regulation of the mammalian fatty acid elongases and their potential role in lipid metabolism are discussed and both the biochemical functions of the proteins, as well as their role in a more physiological context are considered.
921 citations
TL;DR: It has now been established that the synthesis of 22-carbon acids with their ¢rst double bond at position 4 requires an acyl-CoA-dependent v4 desaturase.
911 citations
TL;DR: The first part of this review summarizes the current knowledge concerning elongases and desaturases and focuses on the insights gained from studies with these mice, as well as from investigations on cell cultures.
837 citations
TL;DR: Northern analysis revealed that the brain contained an amount of Δ-6 desaturase mRNA that was several times greater than that found in other tissues including the liver, lung, heart, and skeletal muscle.
668 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 10 |
| 2024 | 26 |
| 2023 | 24 |
| 2022 | 53 |
| 2021 | 42 |
| 2020 | 54 |