Topic
ERBIN Gene
About: ERBIN Gene is a research topic. Over the lifetime, 3 publications have been published within this topic receiving 54 citations.
Papers
Patent•
18 May 2018
TL;DR: In this paper, an induced pluripotent stem cell (iPS) was prepared by introducing a transcription factor and an Erbin gene into skin fibroblasts and carrying out cell culture to allow the skin fibrosblasts to undergo reprogramming.
Abstract: The invention discloses an induced pluripotent stem cell and its preparation method and application. The induced pluripotent stem cell is prepared by introducing a transcription factor and an Erbin gene into skin fibroblasts and carrying out cell culture to allow the skin fibroblasts to undergo reprogramming. Experimental results show that the introduction of the Erbin gene and four genes, i.e., OSKM, into the skin fibroblasts together can improve the reprogramming efficiency of human iPS cells, and the obtained iPS cells can maintain pluripotency for a long time during in-vitro subculturing;and the preparation method provided by the invention overcomes the defects of low reprogramming efficiency and proneness o differentiation during passage of traditional iPS reprogramming methods.
Patent•
6 Sep 2019
TL;DR: In this paper, the role of Erbin gene in regulating tumor-immune microenvironment in colorectal cancer lung metastasis and its mechanism was clarified, and an application of the Erbin antagonistic substances in preparation of drugs for control of lung cancer metastasis was revealed.
Abstract: The invention discloses an application of Erbin in preparation of detection and treatment products for colorectal cancer lung metastasis. The invention clarifies the role of Erbin in regulating tumorimmune microenvironment in colorectal cancer lung metastasis, clarifies the role of Erbin in regulating IgA B cells-mediated CD8 T cells in colorectal cancer lung metastasis and its mechanism, and provides an application of Erbin antagonistic substances in preparation of drugs for control of colorectal cancer lung metastasis. The application proves that the deletion of Erbin gene in B cells can regulate IgA CD138 cells, IgA CD138 cells detected in the lung tissue of Erbin transgenic animals in B cells with colorectal cancer lung metastasis are significantly higher than that in the control group, and the detected IgA protein in serum of the transgenic mice is significantly higher than that in the control group. The cell is found to have low expression of PD1. Moreover, the IgA CD138 cells can kill colorectal cancer cells through the cell killing effect of CD8 T cells, which can inhibit lung metastasis of colorectal cancer.
TL;DR: Erbin is defined as a novel negative modulator of Smad2/Smad3 functions and the physiological role of Erbin is expanded to the regulation of TGFβ signaling.
Abstract: Smad proteins are critical intracellular signaling mediators for the transforming growth factor β (TGFβ) superfamily. Here, we report that Erbin (for “ErbB2/Her2-interacting protein”), which contains leucine-rich repeats and a PDZ (PSD-95/DLG/ZO-1) domain, interacts specifically with Smad3 and, to a lesser extent, with Smad2 through a novel Smad-interacting domain (SID) adjacent to its PDZ domain. Increased expression of Erbin does not affect the level of TGFβ-induced phosphorylation of Smad2/Smad3, but it physically sequesters Smad2/Smad3 from their association with Smad4 and hence negatively modulates TGFβ-dependent transcriptional responses and cell growth inhibition. An isoform of Erbin encoded by an alternatively spliced transcript in human tissues lacks this SID and fails to inhibit TGFβ responses. Consistently, knockdown of the endogenous Erbin gene with short hairpin RNA enhances TGFβ-induced antiproliferative and transcriptional responses. In addition, Erbin suppresses activin/Smad2-dependent, but not BMP/Smad1-mediated, induction of endogenous gene expression in Xenopus embryos. Therefore, these results define Erbin as a novel negative modulator of Smad2/Smad3 functions and expand the physiological role of Erbin to the regulation of TGFβ signaling.
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2019 | 1 |
| 2018 | 1 |
| 2007 | 1 |