TL;DR: Quantitative measurements of iliac bone histology, serum parathyroid hormone levels, and clinical history show the presence of more advanced osteitis fibrosa in children with epiphysiolysis than in those without and a good correlation was found between serum parathormone levels and osteoclastic resorption, endosteal fibrosis as well as osteoid.
Abstract: Clinical, biochemical, roentgenological, and histological features of slipped epiphyses (epiphysiolysis) in 11 out of 112 children with renal osteodystrophy have been analysed. Characteristic age-related patterns of involvement of different epiphyses are described. Quantitative measurements of iliac bone histology, serum parathyroid hormone levels, and clinical history show the presence of more advanced osteitis fibrosa in children with epiphysiolysis than in those without. A good correlation was found between serum parathormone levels and osteoclastic resorption, endosteal fibrosis as well as osteoid. Histological studies show that the radiolucent zone between the epiphyseal ossification centre and the metaphysis in x-rays is not caused by accumulation of cartilage and chondro-osteoid (as usually found in vitamin D deficiency rickets) but by the accumulation of woven bone and/or fibrous tissue. The response to vitamin D therapy in most cases was good. Parathyroidectomy was required in only one case.
TL;DR: Radiological and pathological examination of femoral heads obtained at the time of total hip replacement for osteoarthritis demonstrate characteristic abnormalities accompanying the 'tilt deformity', and it would appear that, in most patients, this pattern of Femoral head migration results not from epiphysiolysis but from a remodelling process in the osteOarthritic joint.
TL;DR: In 16 patients still in growth stage who were suffering from a shortened limb from 5 to 12 cm attributable to a varied etiology, the tibia was lengthened by distraction, hence, achieving separation of the epiphysis (distraction epiphysiolysis), justifying the conclusion that this method is a valuable addition to the accepted techniques for limb lengthening.
Abstract: In 16 patients still in growth stage who were suffering from a shortened limb from 5 to 12 cm attributable to a varied etiology, the tibia was lengthened by distraction, hence, achieving separation of the epiphysis (distraction epiphysiolysis). Lengthening of the tibia from 5 to 10 cm was attained with remarkably minor and infrequent complications. The fact that distraction epiphysiolysis is a blood less procedure, that it allows the formation of a bone segment which is qualitatively and quantitatively suitable to its functional needs, and that all of this is achieved in a reasonably short period, justifies the conclusion that this method is a valuable addition to the accepted techniques for limb lengthening.
TL;DR: The tibiae of 41 growing sheep were lengthened by distraction epiphysiolysis, and new bone tissue gradually formed, which in time developed into a neometaphysis with a new cortex that was capable of supporting normal body weight.
Abstract: The tibiae of 41 growing sheep were lengthened by distraction epiphysiolysis. The distraction apparatus was applied for varying periods of time to the proximal epiphysis of a tibia; the contralateral tibia was used as the control. Daily application of the distraction force initially induced a fracture within the growing cartilage, and then progressively increased the distance between epiphysis and metaphysis. In the newly created space, new bone tissue gradually formed, which in time developed into a neometaphysis with a new cortex. This neometaphysis gradually acquired radiographic characteristics resembling those of control tibia, and they were capable of supporting normal body weight. Elongation of the bone ranged between 30 and 100 mm. Except in one incident of sepsis, no significant changes were observed in the structures adjoining the elongation area, nor in the soft tissue. In general, bone growth was not affected, although premature fusion of the epiphysis occurred in a few cases.