Topic
Emaciation
About: Emaciation is a research topic. Over the lifetime, 522 publications have been published within this topic receiving 8628 citations.
Papers published on a yearly basis
1 / 2
Papers
TL;DR: Clinical characterization of chronic wasting disease and pathologic evidence supporting the conclusion that the disease is a specific spontaneously occurring form of spongiform encephalopathy are presented.
Abstract: In the past 12 years (1967–79) a syndrome we identify as chronic wasting disease has been observed in 53 mule deer (Odocoileus hemionus hemionus) and one black-tailed deer (Odocoileus hemionus columbianus) held in captivity in several wildlife facilities in Colorado and more recently in Wyoming. Clinical signs were seen in adult deer and included behavioral alterations, progressive weight loss and death in 2 weeks to 8 months. Gross necropsy findings included emaciation and excess rumen fluid admixed with sand and gravel. Consistent histopathologic change was limited to the central nervous system and characterized by widespread spongiform transformation of the neuropil, single or multiple intracytoplasmic vacuoles in neuronal perikaryons and intense astrocytic hypertrophy and hyperplasia. Presented is a clinical characterization of chronic wasting disease and pathologic evidence supporting the conclusion that the disease is a specific spontaneously occurring form of spongiform encephalopathy.
818 citations
Journal Article•
TL;DR: The historic, physical, laboratory, and histologic findings for 74 cats with chronic renal disease were reviewed, and the most common clinical signs detected by owners were lethargy, anorexia, and weight loss.
Abstract: The historic, physical, laboratory, and histologic findings for 74 cats with chronic renal disease were reviewed. Most cats were older, and no breed or sex predilection was detected. This most common clinical signs detected by owners were lethargy, anorexia, and weight loss. Dehydration and emaciation were common physical examination findings. Common laboratory findings were nonregenerative anemia, lymphopenia, azotemia, hypercholesterolemia, metabolic acidosis, hyperphosphatemia, and isosthenuria. The most common morphologic diagnosis was chronic tubulointerstitial nephritis of unknown cause. The other pathologic diagnoses were renal lymphosarcoma, renal amyloidosis, chronic pyelonephritis, chronic glomerulonephritis, polycystic renal disease, and pyogranulomatous nephritis secondary to feline infectious peritonitis.
275 citations
TL;DR: Hypoleptinemia, as a result of the food restriction, may represent the initial trigger for the increased activity levels in AN patients and in food-restricted rats.
266 citations
TL;DR: The term "chronic ulcerative colitis" has come to mean a definite disease entity, which presents characteristic clinical, pahologic, proctoscopic and roentgenologic data.
Abstract: The term "chronic ulcerative colitis" has come to mean a definite disease entity, which presents characteristic clinical, pahologic, proctoscopic and roentgenologic data. Clinically, the disease is characterized by frequent rectal discharges of mucus, blood and pus; the presence of diarrhea depends on the extent of involvement of the colon and the severity of the disease. Usually the infection begins in the rectum and spreads upward, and frequently affects the entire colon. If, therefore, the lesions involve only the rectum and rectosigmoid, the stools may be scybalous and the patient may complain of constipation, while having twelve or more bloody, purulent rectal emissions daily. The result of the long-continued passage of blood and the toxemia from the severely infected colon is general wasting, anemia, emaciation and, eventually, chronic invalidism. Obviously the symptoms of this disease may be readily confused with other conditions in which mucus, blood and sometimes pus are discharged
192 citations
TL;DR: A seven-year-old male elk was euthanized and necropsied after having a 3-week history of body weight loss, emaciation, excessive salivation, teeth grinding, fever, anorexia, and respiratory distress, the first case of CWD occurring outside of the U.S.A.
Abstract: A seven-year-old male elk (Cervus elaphus nelsoni) was euthanized and necropsied after having a 3-week history of body weight loss, emaciation, excessive salivation, teeth grinding, fever, anorexia, and respiratory distress The elk was imported into Korea from Canada on March 9, 1997 Gross pathologic findings were restricted to a diffuse fibrinous pneumonia Microscopic lesions included mild neuronal vacuolation and spongiform change in the neuropil of selected brain stem nuclei and generalized astrocytosis Immunohistochemistry for protease-resistant prion protein (PrPres) was positive in all brain sections but more pronounced in the section of the obex of the medulla And the PrPres was also detected by western immunoblotting in the brain and spinal cord All the remaining elk and deer that had been in contact with this elk were destroyed and negative for chronic wasting disease (CWD) To our knowledge, this is the first case of CWD occurring outside of the USA and Canada
167 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 8 |
| 2024 | 14 |
| 2023 | 33 |
| 2022 | 44 |
| 2021 | 17 |
| 2020 | 8 |