Topic
EC50
About: EC50 is a research topic. Over the lifetime, 39 publications have been published within this topic receiving 1028 citations. The topic is also known as: EC50.
Papers published on a yearly basis
Papers
TL;DR: Data indicate that a good alternative test may be found for predicting the long-term human toxicity, and a good correlation was found between the EC50(6w) and the human acute toxicity.
98 citations
TL;DR: The results of this study showed that DMBPO is cytotoxic to cancer cells and possesses antioxidant property.
83 citations
TL;DR: It is concluded that the frequently observed low sensitivity of in vitro cytotoxicity test systems, compared to fish acute toxicity assays, at least in part, can be explained by differences in the availability of chemicals in vitro and in vivo.
78 citations
TL;DR: Fluorescent carbon dots (CDs) are prepared from a natural resource Carica Papaya leaves, by sand bath method as discussed by the authors . But the CDs were not used for biomedical applications like free radical scavenging activity, antioxidant activity, and in vitro anti-inflammatory activity.
Abstract: Fluorescent carbon dots (CDs) are prepared from a natural resource Carica Papaya Leaves, by sand bath method. The as-synthesized CDs optical and structural properties were characterized by UltraViolet-Visible, FT- IR, and fluorescence spectroscopy. Also the size, shape, and particle size distribution was studied using Transmission electron microscopy technique. These CDs were examined for biomedical applications like free radical scavenging activity using DPPH assay, antioxidant activity using phosphomolybdate assay, and in vitro anti-inflammatory activity using membrane stabilization protocol. The CDs exhibited excellent biological activities at lower concentrations and showed notable half-maximal effective concentration (EC50). The EC50 of free radical scavenging activity (27.6 μg/mL), antioxidant activity (23.00 μg/mL), and in vitro anti-inflammatory activity (15.52 μg/mL) signifies that CDs can be potential therapeutic agents.
70 citations
TL;DR: The results suggest that Zn was the major developmental toxicant in the sediment extracts and may be useful for determining potential toxicity in the event metals are leached from aquatic sediments by dredging or acidification.
Abstract: The effects of metal-contaminated sediment extracts and a reference toxicant (zinc sulfate) were determined by examining the developmental morphology, growth and mortality of exposed fathead minnow (Pimephales promelas) and frog (Xenopus laevis) embryos. Sediments from two contaminated stream sites were extracted with reconstituted culture water at various pH values for 24 h. Developmental toxicity tests were performed using the frog embryo teratogenesis assay-Xenopus (FETAX) protocol. The results suggest that Zn was the major developmental toxicant in the sediment extracts. The measured Zn concentration in the sediment extracts that caused malformation in 50% of the fish embryos (EC50) was 0.5 to 1.4 mg/L (normalized to 100 mg/L hardness). EC50 values for the reference toxicant tests were 0.6 and 0.8 mg/L Zn. The frog embryo EC50 for the extracts ranged from 2.2 to 3.6 mg/L Zn and was 3.6 mg/L Zn in the reference toxicant test. In 67% of the tests, malformation was a more sensitive endpoint than growth inhibition. Mortality was the least sensitive endpoint, that is, the LC50s in the reference toxicant tests were 3.6 mg/L Zn for the fathead minnow and 34.5 mg/L for the frog. The extraction procedure may be useful for determining potential toxicity in the event metals are leached from aquatic sediments by dredging or acidification.
61 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 32 |
| 2024 | 62 |
| 2023 | 216 |
| 2022 | 375 |
| 2021 | 12 |
| 2020 | 4 |