TL;DR: Observations on the potassium fluxes of left (quiescent) and right (spontaneously beating) rabbit auricles under the influence of noradrenaline and adrenaline are described and a distinction is made between effects on the fluxes through the resting membrane, and on fluxes in spontaneously contracting tissue.
Abstract: The rate and force of rhythmic contraction in the heart are increased by adrenaline (Oliver & Schafer, 1895; Elliott, 1905) and noradrenaline (Ahlquist, 1948). Adrenaline increases the slope of the diastolic prepotential in pace-maker cells of spontaneously beating auricles (West, Falk & Cervoni, 1956), and both drugs increase the rate of repolarization after an action potential in all auricular cells (Brooks, Hoffman, Suckling & Orias, 1955). As repolarization after an action potential is generally assumed to be due to the passive efflux of potassium from the tissue, it would be expected that adrenaline and noradrenaline would accelerate this flux. There appears to be little published information about the effect of these amines on the resting membrane potential in quiescent left auricles, so it is difficult to predict what changes in potassium fluxes might be expected. The present paper describes observations on the potassium fluxes of left (quiescent) and right (spontaneously beating) rabbit auricles under the influence of noradrenaline and adrenaline, and enables a distinction to be made between effects on the fluxes through the resting membrane, and on fluxes in spontaneously contracting tissue.
TL;DR: One of the early theories of tympanic muscle function was that these muscles, or at least the tensor tympani muscle, serves the purpose of regulating the transmission of sounds through the middle ear.
Abstract: One of the early theories of tympanic muscle function was that these muscles, or at least the tensor tympani muscle, serves the purpose of regulating the transmission of sounds through the middle ear. In its complete form this theory asserted that the muscles are able to augment faint sounds and to moderate the intensity of excessively strong ones. Molinettus is credited with the first presentation of this theory; according to Morgagni,' he claimed that the tensor tympani muscle excludes strong and uncomfortable noises and amplifies weak ones.
TL;DR: In this paper, the authors developed a surgical technique for combined esthetic and functional reconstruction with a minimum of operations and evaluated its results with two patients with third-degree microtia and congenital aural atresia.
Abstract: Objectives Due to their embryological development, auricular atresia and severe microtia are, in most cases, combined malformations. The aims of this study were firstly to develop a surgical technique for combined esthetic and functional reconstruction with a minimum of operations and secondly to evaluate its results. Study design Prospective clinical evaluation. Patients and methods Fifty-two patients with third-degree microtia and congenital aural atresia with a sound-conducting block of about 50 dB were treated. In the first operation, autogenous cartilage was harvested, and the auricular framework was fabricated and implanted. In addition, the tympanic membrane and the external ear canal were prefabricated, and stored in a subcutaneous pocket. In the second step, the elevation of the new framework was combined with the operation for atresia, utilizing the prefabricated tympanic membrane and external ear canal. In the third step, the cavum concha was deepened, and the external ear canal was opened and covered with a skin graft. Results In total, 76% of the patients had a final conductive hearing loss of 30 dB or less. No restenosis of the new external ear canal was observed. The esthetic results of the constructed auricles are shown in this report. Conclusion With this combination of plastic surgery for the auricle and functional surgery for the middle ear, no additional operations are necessary and the prefabrication of the external ear canal and the tympanic membrane gives stable and reliable results. This combined technique offers the best chance of optimal esthetic and functional rehabilitation for patients with these malformations.