TL;DR: Stimulation to the contralateral dorsolateral prefrontal cortex markedly impaired procedural implicit learning, as documented by the lack of significant change in response times during the task.
Abstract: We studied the role of the dorsolateral prefrontal cortex in procedural learning. Normal subjects completed several blocks of a serial reaction time task using only one hand without or with concurrent non-invasive repetitive transcranial magnetic stimulation. To disrupt their function transiently, stimulation was applied at low intensity over the supplementary motor area or over the dorsolateral prefrontal cortex contralateral or ipsilateral to the hand used for the test. Stimulation to the contralateral dorsolateral prefrontal cortex markedly impaired procedural implicit learning, as documented by the lack of significant change in response times during the task. Stimulation over the other areas did not interfere with learning. These results support the notion of a critical role of contralateral dorsolateral prefrontal structures in learning of motor sequences.
TL;DR: It is concluded that the majority of prefrontal neurons were functionally stable during the performance of well-learned tasks, given that neurons with 4 different types of task selectivity were found to be functionally stable.
Abstract: Stable multiday recordings from the dorsolateral prefrontal cortex of 2 monkeys performing 2 Go/NoGo visual-discrimination tasks (one requiring well-learned responses, the other requiring learning)...
TL;DR: The present study reveals that this selective uptake of Zn65 is confined to the lateral portion of the dorsolateral prostate, suggesting a functional difference between the two parts of the gland.
Abstract: SummaryThe authors reported previously that the dorsolateral prostate of the rat concentrates administered Zn65 from 15–25 times more than any other tissue(1). The present study reveals that this selective uptake of Zn65 is confined to the lateral portion of the dorsolateral prostate, suggesting a functional difference between the two parts of the gland. Histological study also lends evidence to this observation.
TL;DR: DLS score and distraction index measure different components of hip joint stability in dogs.
Abstract: Abstract Objective To determine whether dorsolateral subluxation (DLS) of the femoral head reflects osseous conformation of the coxofemoral (hip) joint and represents a property distinct from maximum passive laxity of the hip joint in dogs. Animals 14 Labrador Retrievers, 16 Greyhounds, 58 Greyhound-Labrador Retriever mixed-breed dogs, and 1 Rottweiler. Procedures DLS of the femoral head (DLS score) and passive laxity of the hip joint (distraction index) were determined radiographically in 3 groups of dogs: not treated (167 joints of 84 dogs); before and after injecting 2 ml of hyaluronan into 25 hip joints of 13 dogs; and before and after unilateral triple pelvic osteotomy in 5 dogs. Results of the 2 methods were compared for each group. Results In untreated dogs, the correlation coefficient ( r ) of DLS score versus distraction index was −0.73 and −0.69 for 84 left and 83 right hip joints, respectively. Mean coefficient of determination ( r 2 ) for both hips was 0.5. Mean DLS score did not differ before and after intra-articular injection of hyaluronan into either hip joint, whereas mean distraction index increased significantly after intra-articular injection. Unilateral triple pelvic osteotomy resulted in a significant increase in DLS score, compared with values obtained before surgery. However, distraction index before and after surgery did not differ significantly. Conclusions and Clinical Relevance The DLS test assesses the congruity of the acetabulum and the femoral head in a canine hip joint and thus represents a characteristic distinct from maximum passive laxity. The DLS score and the distraction index evaluate different components of hip joint stability. ( Am J Vet Res 1999;60:1571–1576)