Doramectin

TL;DR: Doramectin was extensively evaluated in cattle using an experimental micelle formulation, proving highly effective in cattle infected with Ostertagia ostertagi, Cooperia oncophora and Dictyocaulus viviparus when administered subcutaneously at 200 micrograms kg-1.

TL;DR: It is concluded that the pharmacokinetic differences between doramectin and ivermectin may explain the longer duration of preventive efficacy of dor AMT, and this was explained by a lower clearance, a lower volume of distribution and, probably, a higher bioavailability of dorsumectin over iverMectin.

TL;DR: It was concluded that resistance of trichostrongylid nematodes to the avermectin/milbemycin class of compounds in grazing cattle of the Humid Pampa, Argentina, may be strongly established on farms where cattle are treated at frequent intervals throughout the year.

TL;DR: It was concluded that a 500 microg kg(-1) pour-on administration of doramectin and ivermectin led to an overall exposure as reflected by the mean AUC, that was 45% higher for dorAmectin compared to iverMectin, and that the relative inter-individual variability was less for dOramect in than for iver mectin.