Topic
Dock11
About: Dock11 is a research topic. Over the lifetime, 13 publications have been published within this topic receiving 607 citations. The topic is also known as: ACG & ZIZ2.
Papers
TL;DR: This review proposes an update of the recent findings regarding the function of Dock proteins, focusing on their role in the control of cell migration and invasion and the consequences in human diseases.
209 citations
TL;DR: Sequence comparison combined with mutational analysis suggest that CZH2 is a new GEF domain for the Rho family of proteins, a new superfamily that includes the so-called 'CDM' proteins that bind to and activate Rac.
Abstract: The Rho family GTPases Rac, Rho and Cdc42 are critical in regulating the actin-based cytoskeleton, cell migration, growth, survival and gene expression. These GTPases are activated by guanine nucleotide-exchange factors (GEFs). A biochemical search for Cdc42 activators led to the cloning of zizimin1, a new protein whose overexpression induces Cdc42 activation. Sequence comparison combined with mutational analysis identified a new domain, which we named CZH2, that mediates direct interaction with Cdc42. CZH2-containing proteins constitute a new superfamily that includes the so-called 'CDM' proteins that bind to and activate Rac. Together, the results suggest that CZH2 is a new GEF domain for the Rho family of proteins.
188 citations
TL;DR: It is shown that Dock6, a member of the Dock-C subfamily, exchanges GDP for GTP for Rac1 and Cdc42 in vitro and in vivo and is found that, in mouse N1E-115 neuroblastoma cells, expression of Dock6 is increased following differentiation.
110 citations
TL;DR: The cloning of zizimin2 is reported, identified in a screen for genes enriched in germinal center B cells, which has similar primary structures and both proteins bound and activated CDC42 but not the Cdc42‐related proteins TC10 or TCL.
70 citations
TL;DR: The rapid and distinctive induction of Dock10 expression by IL4 in CLL and normal PB-B cells suggests a role for Dock10 in IL4-induced B-cell activation, and could represent a point of convergence for IL4 signalling and small Rho GTPase function in B cells.
50 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 2 |
| 2020 | 1 |
| 2018 | 1 |
| 2014 | 1 |
| 2012 | 1 |
| 2010 | 1 |